Coal slurry is an essential component of mining operations, accounting for more than half of operating costs. Dewatering technology is simultaneously confronted with obstacles and possibilities, and it may yet be improved as the crucial step for reducing the ultimate processing cost. Coagulation/flocculation is used as a dewatering process that is reasonably cost-effective and user-friendly. This paper reviews application of different coagulants/flocculants and their combinations in dewatering mechanisms. In this context, various polymeric flocculants are discussed in the coal slurry in depth. Many operational parameters that influence the performance of coal slurry flocculation are also presented. Furthermore, a discussion is provided on the mechanism of flocculants’ interaction, the strategy of combining flocculants, and efficient selection methods of flocculants. Finally, coagulation/flocculation remaining challenges and technological improvements for the better development of highly efficient treatment methods were highlighted, focusing on the intricate composition of slurry and its treatment difficulties.