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L’INDAZOLE ET SES DERIVES : SYNTHESES, REACTIVITES ET PROPRIETES BIOLOGIQUES

descriptionPublicationkeyboard_double_arrow_right Article 24 Mar 2018 French Publisher:Journal Marocain de Chimie Hétérocyclique

Authors: Ben-Yahia, Ali; Benchidmi, Mohammed; Essassi, El Mokhtar;

doi: 10.48369/imist.prsm/jmch-v17i1.11871

L’INDAZOLE ET SES DERIVES : SYNTHESES, REACTIVITES ET PROPRIETES BIOLOGIQUES

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Abstract

In this review paper, we wish to discuss and summarize indazoles synthesis and functionalization such as bromination, iodination, N-alkylation, N-arylation, Suzuki–Miyaura cross coupling and direct arylation. Then, in the second part, various drugs containing indazole system and the biological properties of indazole derivatives, including antiinflammatory, antimicrobial, anti-HIV, anticancer, antagonist TRPV1, antihypertensive, and other applications will be presented and discussed.

Journal Marocain de Chimie Hétérocyclique, Vol 17, No 1 (2018)

Keywords

Indazole, couplage de Suzuki-Miyaura, Arylation directe, N-Alkylation, NArylation., biological properties

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