The present study aims to investigate the effectiveness of pictured letters mnemonics strategy in learning similarEnglish language letters among students with learning disabilities in Saudi Arabia according to experimental group(1) and (2), control group, gender, and interaction between them. The study sample comprised (90) students withlearning disabilities who were randomly distributed to three equal groups. While the first experimental group wastaught using the modified letter method, the second experimental group was taught using the method of bothmodified and abstract letters, and the control group was taught in the traditional way. To measure the effectiveness ofthe strategy, the authors applied (pre, post, and follow-up) tests. As a result, two-way ANOVA indicated that therewere significant differences attributed to the teaching method, in favor of the method of both modified and abstractletters, while there were no statistically significant differences due to gender or interaction between the teachingmethod and gender. The same results were obtained from the follow-up test. Accordingly, a set of recommendationswere made.