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Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"
Article . 1994
Data sources: Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"
https://pubmed.ncbi.nlm.nih.go...
Article . 1994
Data sources: Europe PubMed Central
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Comparison between transforming growth factor alpha and epidermal growth factor in the protection of rat gastric mucosa against drug-induced injury.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1994 Italy English Journal:The Italian journal of gastroenterology, volume 26 (issn: 0392-0623, Copyright policy )
Authors: ROMANO, Marco; E. R. KRAUSE; C. R. BOLAND; R. J. COFFEY;

pmid: 7522648

handle: 11591/226707

Comparison between transforming growth factor alpha and epidermal growth factor in the protection of rat gastric mucosa against drug-induced injury.

Abstract

This study was designed to compare the protective effect of recombinant human TGF alpha or EGF against drug-induced damage to the rat gastric mucosa. Parenteral administration of TGF alpha and EGF prevented 100% ethanol-induced mucosal injury to a similar extent. Furthermore, both peptides, in non-antisecretory doses, significantly decreased the gastric mucosal damage brought about by acidified aspirin. TGF alpha and EGF did not afford significant protection of the gastric mucosa when administered orogastrically. We also evaluated the effect of TGF alpha and EGF on insoluble (adherent) gastric mucin and found that both compounds dose-dependently stimulated adherent mucin in a time frame consistent with their protective effect. In conclusion, TGF alpha and EGF are equally effective in preventing drug-induced injury to the rat gastric mucosa.

Country
Italy
Related Organizations
Keywords

Male, Aspirin, Epidermal Growth Factor, Ethanol, Gastric Mucins, Transforming Growth Factor alpha, Recombinant Proteins, Rats, Gastric Acid, Rats, Sprague-Dawley, Gastric Mucosa, Animals, Humans

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    		 21
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
21
Average
Top 10%
Top 10%
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