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MMW - Fortschritte der Medizin

Article . 2004

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[Acamprosate--new preclinical research aspects].

descriptionPublicationkeyboard_double_arrow_right Article 22 Dec 2004 German Journal:MMW Fortschritte der Medizin, volume 145 Suppl 3 (issn: 1438-3276,

Authors: R, Spanagel; K, Mann;

pmid: 15490768

[Acamprosate--new preclinical research aspects].

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Abstract

Acamprosate has been shown to be effective and safe in relapse prevention of alcoholism. The effect of acamprosate is explained by a functional antagonistic action on the N-methyl-D-aspartate (NMDA) receptor. Under normal physiological conditions acamprosate augments the functionality of the NDMA receptor, but it inhibits the overactivity of that receptor triggered by alcohol abuse and withdrawal. In addition, conditioned withdrawal phenomena that can lead to a relapse, are also reduced. The substance is not a substitution drug, nor does it have addictive potential. Moreover, it also has a neuroprotective action. Whether acamprosate has a role as a neuroprotective agent in humans needs to be investigated.

Keywords

Ethanol, Taurine, Acamprosate, Research, Drug Evaluation, Preclinical, Brain, Receptors, N-Methyl-D-Aspartate, Rats, Alcoholism, Neuroprotective Agents, Animals, Humans, Alcohol Deterrents

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