Effects of acute and chronic ethanol administration on phosphoinositide metabolism in mouse brain.
Copyright policy )Effects of acute and chronic ethanol administration on phosphoinositide metabolism in mouse brain.
A radiotracer technique in combination with lithium injection was used to probe the effects of acute and chronic ethanol administration on poly-phosphoinositide turnover in mouse brain. C57Bl/6J mice were injected intracerebrally with 3H-inositol to label the inositol phospholipids and inositol phosphates in brain. Subsequently, the accumulation of labeled inositol monophosphates was assessed 4 hr after i.p. injection of lithium (6 meq/kg body wt). Using this experimental paradigm, results indicated a significant increase in labeled inositol monophosphates in the chronic ethanol group and a decrease in the same compound in animals after acute ethanol intoxication.
Mice, Inbred C57BL, Mice, Ethanol, Phosphatidylinositol Phosphates, Animals, Brain, Lithium, Phosphatidylinositols, Tritium, Models, Biological, Drug Administration Schedule, Inositol
Mice, Inbred C57BL, Mice, Ethanol, Phosphatidylinositol Phosphates, Animals, Brain, Lithium, Phosphatidylinositols, Tritium, Models, Biological, Drug Administration Schedule, Inositol
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).2 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!