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Article . 2007

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[Mechanisms of 232Th effects on Chlorella vulgaris Beljer and modifications of it's toxic effect with caffeine and buthionine sulfoximine].

descriptionPublicationkeyboard_double_arrow_right Article 22 Mar 2007 Russian Journal:Radiatsionnaia biologiia, radioecologiia, volume 46 (issn: 0869-8031,

Authors: T I, Evseeva; T A, Maĭstrenko; S A, Geras'kin; E S, Belykh;

pmid: 17323704

[Mechanisms of 232Th effects on Chlorella vulgaris Beljer and modifications of it's toxic effect with caffeine and buthionine sulfoximine].

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Abstract

232Th effects and its modifications with caffeine and D, L-buthionine-(S, R)-sulphoximine in Chlorella vulgaris Beijer cells was studied with use an optical density measure after 24 hours growth. Was shown relationship between concentration and toxic effect that is nonlinear and characterized with three parts different in induced damages level. In the first concentration range (0.001-1.551 micromol/l) chlorella growth parameters don't significantly differ from control ones. In the second one (1.724-3.017 micromol/1) statistically significant increase of optical density is but the effect does not dependent on 232Th concentration. The 232Th concentration (>3.448 micromol/l) increase the monotonous decrease in optical density was observed. The main role in 232Th toxic effect decrease make processes of DNA reparation, but not free radical scavenging with glutathione.

Keywords

Time Factors, DNA Repair, Dose-Response Relationship, Drug, Thorium, Dose-Response Relationship, Radiation, Radiation-Protective Agents, Free Radical Scavengers, Glutathione, Caffeine, Biomass, Chlorella vulgaris, Buthionine Sulfoximine, DNA Damage

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