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Revue Médicale Suiss...arrow_drop_down

Revue Médicale Suisse

Article . 2007

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[Anti-HLA antibody detection and rejection in kidney transplantation: impact of the new technologies].

descriptionPublicationkeyboard_double_arrow_right Article 31 Jul 2007 French Journal:Revue medicale suisse, volume 3 (issn: 1660-9379,

Authors: D, Georgescu; S, Ferrari-Lacraz; J, Villard;

pmid: 17552259

[Anti-HLA antibody detection and rejection in kidney transplantation: impact of the new technologies].

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Abstract

In kidney transplantation, hyperacute rejection is mediated by anti-HLA antibody which are also responsible for antibody-mediated acute rejection. In addition anti-HLA antibody are also implicated in the physiopathological mechanism of chronic rejection. The gold standard methodology to detect anti-HLA antibody is based on the complement-dependant-cytotoxicity. This technic is neither specific nor sensitive. New powerful technologies, which are specific and very sensitive, have been developed like Elisa and flow cytometer with fluorescent micro-beads to detect anti-HLA antibody. In this article, we review the importance of anti-HLA antibody in humoral rejection. We also discussed the clinical relevance of the detection of anti-HLA antibody by these new approaches.

Keywords

Graft Rejection, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Kidney Transplantation, Antibodies, HLA Antigens, Humans

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