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Article . 1986

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[Biochemical aspects of dependence on alcohol].

Name: [Biochemical aspects of dependence on alcohol].
Creator: R, Nordmann
Keywords: Neurotransmitter Agents, Ethanol, Membrane Fluidity, Synaptic Membranes, Brain, Membrane Proteins, Acetaldehyde, 3. Good health, Rats, Substance Withdrawal Syndrome

descriptionPublicationkeyboard_double_arrow_right Article 28 Mar 1986 French Journal:Acta psychiatrica Belgica, volume 85 (issn: 0300-8967,

Authors: R, Nordmann;

pmid: 2869646

[Biochemical aspects of dependence on alcohol].

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Abstract

Chronic alcohol intoxication is able to modify the lipid structure and fluidity of synaptosomal membranes and influence hereby the activity of some membraneous enzymes and receptors. These changes could play a key role in the development of alcohol tolerance and dependence. This "membraneous hypothesis" allows to explain, at least in part, the influence of nutritional factors as well as of differences in genetic or individual susceptibility on alcohol dependence. It suggests furthermore the possibility of prevention of alcohol dependence through dietary and pharmacological means.

Keywords

Neurotransmitter Agents, Ethanol, Membrane Fluidity, Synaptic Membranes, Brain, Membrane Proteins, Acetaldehyde, Rats, Substance Withdrawal Syndrome, Alcoholism, Membrane Lipids, Mice, Animals

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3. Good health,