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Article . 1979

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[Biochemical mechanisms for the effect of alcohol on the brain].

descriptionPublicationkeyboard_double_arrow_right Article 16 Aug 1979 German Journal:Psychiatrie, Neurologie, und medizinische Psychologie, volume 31 (issn: 0033-2739,

Authors: H, Kluge; J, Neumann; K, Seidel;

pmid: 36641

[Biochemical mechanisms for the effect of alcohol on the brain].

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Abstract

This paper reviews and discusses basic knowledge of biochemical mechanisms of action of ethanol upon the central nervous system, the emphasis being on effects upon cerebral membrane structures and processes as well as mechanisms of chemical synaptic transmission. Results of detailed studies into material and steric changes in membranes, ion-dependent adenosine triphosphatases, variations in ion balance, effects upon cyclic nucleotides, influences on special transmitter systems, and mechanisms of formation of morphine-analogous condensation products are presented. In addition, open questions are derived and formulated in problem complexes.

Keywords

Neurotransmitter Agents, Alcohol Drinking, Ethanol, Brain, Acetaldehyde, Calcium-Transporting ATPases, Synaptic Transmission, Ion Channels, Membrane Potentials, Receptors, Neurotransmitter, Alcoholism, Electrolytes, Animals, Humans, Sodium-Potassium-Exchanging ATPase, Monoamine Oxidase, Adenylyl Cyclases, Synaptosomes

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