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Alcohol Research and Health

Article . 2007

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Biological processes underlying co-use of alcohol and nicotine: neuronal mechanisms, cross-tolerance, and genetic factors.

descriptionPublicationkeyboard_double_arrow_right Article 02 May 2007 English Journal:Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, volume 29 (issn: 1535-7414,

Authors: Douglas, Funk; Peter W, Marinelli; Anh D, Lê;

pmid: 17373407

pmc: PMC6527043

Biological processes underlying co-use of alcohol and nicotine: neuronal mechanisms, cross-tolerance, and genetic factors.

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Abstract

Alcohol and nicotine are two of the oldest and most commonly used recreational drugs, and many people use both of them together. Although their ready availability likely contributes to the strong correlation between alcohol and nicotine use, several lines of evidence suggest that biological factors play a role as well. For example, both alcohol and nicotine act on a brain system called the mesolimbic dopamine system, which mediates the rewarding and reinforcing properties of both drugs. Modification of the activities of the mesolimbic dopamine system can interfere with the effects of both alcohol and nicotine. Another mechanism that may contribute to alcohol-nicotine interactions is cross-tolerance to the effects of both drugs. Finally, genetic studies in humans and of selectively bred mouse and rat strains suggest that shared genetic factors help determine a person's liability to use or abuse both alcohol and nicotine.

Keywords

Neurons, Motivation, Nicotine, Ethanol, Dopamine, Brain, Drug Tolerance, Tobacco Use Disorder, Receptors, Nicotinic, Rats, Mice, Mesencephalon, Neural Pathways, Limbic System, Animals, Humans, Drug Interactions, Genetic Predisposition to Disease, Arousal, Alcohol-Related Disorders

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