Attenuation of H-Pylori-Induced Gastric Pathology in C57bl/6 Mice by Co-Infection with Enterohepatic Helicobacters Is Helicobacter Species-Dependent
Attenuation of H-Pylori-Induced Gastric Pathology in C57bl/6 Mice by Co-Infection with Enterohepatic Helicobacters Is Helicobacter Species-Dependent
To investigate how concurrent infection with an enterohepatic helicobacter species (EHS) affects H. pylori (Hp)-induced gastric pathology, C57BL/6 mice were inoculated with H. hepaticus (Hh), or H. muridarum (Hm), followed by infection with Hp. Compared to Hp-infected mice, HmHp-infected mice at 6 and 11 months postinoculation (mpi) had markedly attenuated histopathologic activity index (HAI) scores (P Hp> HmHp). Our data suggest: (1) host Th1 responses plays a major role in limiting Hp colonization; (2) EHS-mediated attenuation of the Hp-induced gastric pathology depends on the ability of the individual EHS to suppress both Th1 and IL17 proinflammatory pathways.
National Institutes of Health (U.S.) (NIH grant P30 ES02109)
National Institutes of Health (U.S.) (NIH grant R01CA67529)
National Institutes of Health (U.S.) (NIH grant R01AI51404)
National Institutes of Health (U.S.) (NIH grant T32RR07036)
- Massachusetts Institute of Technology United States
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