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Photophysical and photochemical properties of α-(8-quinolinoxy) zinc phthalocyanine for photodynamic therapy

descriptionPublicationkeyboard_double_arrow_right Conference object , Other literature type 12 Feb 2009Publisher:SPIEJournal:SPIE Proceedings, volume 7,164, page 71640W (issn: 0277-786X,

Authors: Yuehui Lv; Jinping Xue; Huiyun Lin; Buhong Li; Songlin Yu; Shusen Xie;

doi: 10.1117/12.808446

Photophysical and photochemical properties of α-(8-quinolinoxy) zinc phthalocyanine for photodynamic therapy

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Abstract

The photophysical and photochemical properties of a newly developed photosensitizer α-(8-quinolinoxy) zinc phthalocyanine (α-(8-QLO)PcZn) were investigated for application in photodynamic therapy (PDT). The maximal Q band for α-(8-QLO)PcZn in dimethylformamide around 675 nm with the molar extinction coefficient of about 1.89×10 5 mol -1 cm -1 . The fluorescence quantum and singlet oxygen ( 1 O 2 ) yields were determined to be 0.18±0.02 and 0.62±0.03, respectively. α-(8-QLO) PcZn has a diffuse cytoplasmic distribution in nasopharyngeal carcinoma C666-1 cells, and the efficient photodynamic cytotoxicity was observed. Our findings of this study suggest that α-(8-QLO)PcZn is a promising second-generation photosensitizer for PDT.

Related Organizations

Fuzhou University
China (People's Republic of)
Fuzhou University
China (People's Republic of)
Fujian Normal University
China (People's Republic of)
Fujian Normal University
China (People's Republic of)

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medical and health sciences

basic medicine

Fields of Science

medical and health sciences

basic medicine

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