Rats were implanted with stimulating electrodes in the medial forebrain bundle-lateral hypothalamus (MFB-LH). After recovery from surgery, they were assigned to one of two groups equalized for body weight. One group was housed four animals to a cage and animals in the other group were housed individually. After four weeks in these housing conditions, animals were tested during the fifth week for locomotor activity in five daily 15-min sessions, and their reactivity to handling was also measured. During the sixth and seventh weeks, animals were allowed to self-train for brain stimulation (ICSS) during daily 15-min sessions. Animals housed in groups had higher levels of locomotor activity and were less reactive to handling than were animals housed individually. When tested for the acquisition of ICSS, animals housed as a group made more responses than did animals housed individually. These results indicate that, within the time frame of a few weeks, the housing conditions of adult animals caused differences in both unconditioned behavior, such as locomotor activity, and in the acquisition of a highly reinforcing brain self-stimulation task.