In this chapter, the position of Capture, Transport and Storage of CO2 (CTSC) in climate change mitigation is introduced. Then, an overview of CTSC projects in the world is presented. Risks associated to each subsystem and the whole chain are presented. Risks related to the whole chain in a complex sociotechnical framework are classified in eight groups: Technical, Risks related to Project, Social, Policy/Strategy, HSE, Regulatory, Organizational/Human and Financial/Economic. Notions of risk and risk management are also introduced, followed by a general recall of the evolution of risk management approaches. In the last part, available risk management approaches for Capture, Transport and Storage are reviewed individually. Finally, integrated (systemic) approaches are argued as essential need of risk management for CTSC.