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A comparative study of the effect of adriamycin on the sensitivity of mice to whole-body irradiation with 6-MVp photons or fast neutrons (67 MeV p--Be).

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Dec 1980Publisher:Radiological Society of North America (RSNA)Journal:Radiology, volume 137, pages 833-834 (issn: 0033-8419, eissn: 1527-1315,

Authors: Eileen Zabilansky; J. L. Redpath; M. Colman;

doi: 10.1148/radiology.137.3.6777828

pmid: 6777828

A comparative study of the effect of adriamycin on the sensitivity of mice to whole-body irradiation with 6-MVp photons or fast neutrons (67 MeV p--Be).

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Abstract

The effect of Adriamycin (doxorubicin hydrochloride) (10 mg/kg intraperitoneally) on the response of mouse gut to irradiation with 6-MVp photons or fast neutrons (67 MeV p--Be), was assessed with the six-day death endpoint. The drug reduced the LD50/6 by the same factor (approximately 1.25) for both types of radiation. Thus, the radiobiological effectiveness (RBE) (photons/neutrons) for gut damage is unaltered by the addition of Adriamycin. The data indicated no significant effect of drug scheduling if given within 16 hours before or after irradiation.

Related Organizations

University of California, Irvine
United States
University of California, Berkeley
United States

Keywords

Male, Antineoplastic Agents, Fast Neutrons, Intestines, Radiotherapy, High-Energy, Mice, Doxorubicin, Animals, Elementary Particles, Relative Biological Effectiveness

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