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Prosthodontic Research & Practice
Article . 2006 . Peer-reviewed
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A Preliminary Study on a Newly Developed Cell-hybridized Artificial Bone in a Beagle Dog: Bone Marrow Stromal Cells with an Interconnected Porous Hydroxyapatite Scaffold

Authors: Kazuhiko Hayashi; Takayasu Kubo; Kazuya Doi; Yasumasa Akagawa;

A Preliminary Study on a Newly Developed Cell-hybridized Artificial Bone in a Beagle Dog: Bone Marrow Stromal Cells with an Interconnected Porous Hydroxyapatite Scaffold

Abstract

Purpose: This study was performed to clarify the possibility of bone regeneration with a cell-hybridized artificial bone by evaluating bone formation in the beagle dog femur.Methods: Bone marrow stromal cells (BMSCs) /interconnected porous hydroxyapatite (IP-CHA) composites as a cell-hybridized artificial bone were made by the injection of the BMSCs solution into IP-CHA. The distribution of BMSCs in IP-CHA was examined by scanning electron microscopy. Two BMSCs/IP-CHA composites (the BMSCs of one composite were labeled fluorescence) were placed into each of two bone sockets (φ3.7 mm×7 mm) prepared in the right femur of the beagle dog. After 4 weeks of surgery, new bone formation in the socket was examined by light microscopy and fluorescence microscopy.Results: SEM showed well distribution of the injected BMSCs in the pores of IP-CHA. At 4 weeks, new bone formation was detected at the cortical areas of the composites, and injected BMSCs were identified in the new bone area of the interconnected pores. Conclusion: The limited results of this study may suggest that BMSCs/IP-CHA composites as cell-hybridized artificial bone is a possible candidate for bone regeneration.

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
bronze