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Cancer chemopreventive diterpenes from Salvia corrugata

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Dec 2013 Switzerland, Italy Publisher:Elsevier BVJournal:Phytochemistry, volume 96, pages 257-264 (issn: 0031-9422,

Authors: GIACOMELLI, EMANUELA; Bertrand S.; Nievergelt A.; Zwick V.; Simoes Pires C.; Marcourt L.; Rivara Minten E.; +3 Authors

doi: 10.1016/j.phytochem.2013.09.011

pmid: 24120298

handle: 11567/649567

Cancer chemopreventive diterpenes from Salvia corrugata

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Abstract

NMR and NP-HPLC-UV profiling of the exudate of Salvia corrugata revealed that its secondary metabolite composition was largely dominated by α-hydroxy-β-isopropyl-benzoquinone diterpenoids. Among them, four diterpenes not described previously were isolated and identified as fruticulin C (3), 7α-methoxy-19-acetoxy-royleanone (4), 7α,19-diacetoxy-royleanone (5), and 7-dehydroxy-conacytone (7). In addition, the known diterpenes fruticulin A (1), demethyl-fruticulin A (2) and 7α-O-methyl-conacytone (6) were also obtained. The isolated compounds were evaluated for their cancer chemopreventive activity by measuring quinone reductase induction activity and histone deacetylase inhibition. Three compounds (1, 2 and 5) showed promising activity.

Countries

Switzerland, Italy

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Keywords

Icetexane, Salvia corrugata Diterpenes Abietane Icetexane Fruticulin C Quinone reductase Histone deacetylase, Plant Roots, info:eu-repo/classification/ddc/615, NAD(P)H Dehydrogenase (Quinone), Humans, Histone deacetylase, Salvia, Nuclear Magnetic Resonance, Biomolecular, Molecular Structure, Histone Deacetylase Inhibitors, Fruticulin C, Quinone reductase, Italy, Abietanes, Abietane, Diterpenes, Salvia corrugata, ddc: ddc:615

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