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ChemInform Abstract: Synthesis and Biological Evaluation of 14‐Alkoxymorphinans. Part 8. 14‐Methoxymetopon, an Extremely Potent Opioid Agonist.

descriptionPublicationkeyboard_double_arrow_right Article , Journal , Other literature type 19 Sep 1990Publisher:WileyJournal:ChemInform, volume 21 (issn: 0931-7597, eissn: 1522-2667,

Authors: Jörg Mitterdorfer; Andrea Schratz; Helmut Schmidhammer;

doi: 10.1002/chin.199049284 , 10.1002/hlca.19900730623

ChemInform Abstract: Synthesis and Biological Evaluation of 14‐Alkoxymorphinans. Part 8. 14‐Methoxymetopon, an Extremely Potent Opioid Agonist.

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Abstract

Abstract14‐Methoxymetopon (= 5,14‐O‐dimethyloxymorphone; 4)and 14‐ethoxymetopon (5) were synthesized from 14‐hydroxy‐5‐methylcodeinone (6). In the AcOH‐writhing test in mice, compound 4 was found to be ca. 20000 times more potent than morphine.

Related Organizations

University of Innsbruck
Austria

11 Research products, page 1 of 2

Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 20. 14-Phenylpropoxymetopon: An Extremely Powerful Analgesic
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Binding characteristics of [³H]14‐methoxymetopon, a high affinity µ‐opioid receptor agonist
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S159 IN SILICO, IN VITRO AND IN VIVO PROFILES OF DIFFERENTLY SUBSTITUTED 14-METHOXYMETOPON ANALOGUES, HIGH AFFINITY AND POTENT m OPIOID ANTINOCICEPTIVES
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14-Methoxymetopon, a very potent μ-opioid receptor-selective analgesic with an unusual pharmacological profile
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Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	35
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	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%