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Comptes Rendus de l Académie des Sciences - Series III - Sciences de la Vie

Article . 1995

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From the v-mpl oncogene to thrombopoietin.

descriptionPublicationkeyboard_double_arrow_right Article 28 Sep 1995Journal:Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, volume 318 (issn: 0764-4469,

Authors: N, Methia; N, Debili; M, Titeux; W, Vainchenker; F, Wendling;

pmid: 7648360

From the v-mpl oncogene to thrombopoietin.

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Abstract

v-mpl is a mouse oncogene that is part of the genome of the myeloproliferative leukemia virus (MPLV). The cellular homolog gene c-mpl encodes an hematopoietic cytokine receptor restricted to the megakaryocytic lineage of differentiation. Using the Mpl receptor protein, cDNAs corresponding to the receptor ligand were isolated in humans, pigs, dogs and mice. In vivo and in vitro, the recombinant molecule has both the thrombopoietin (TPO) and megakaryocyte-colony stimulating factor (MK-CSF) activities. This molecule (Mpl ligand/TPO/MK-CSF) is the humoral physiological regulator of platelet production.

Keywords

Oncogenes, In Vitro Techniques, Ligands, Leukemia Virus, Murine, Mice, Dogs, Colony-Stimulating Factors, Thrombopoietin, Proto-Oncogene Proteins, Proto-Oncogenes, Animals, Humans, Megakaryocytes

12 Research products, page 1 of 2

Mpl Expression and Functional Role in Human Megakaryocytopoiesis
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Thrombopoietin: Biological Effects Beyond Megakaryopoiesis
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