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To assess the resilience of energy systems, i.e., the ability to recover after an unexpected shock, the system’s minimum state of service is a key input. Quantitative descriptions of such states are inherently elusive. The measures adopted by governments to contain COVID-19 have provided empirical data, which may serve as a proxy for such states of minimum service. Here, we systematize the impact of the adopted COVID-19 measures on the electricity demand. We classify the measures into three phases of increasing stringency, ranging from working from home to soft and full lockdowns, for four major electricity consuming countries of Europe. We use readily accessible data from the European Network of Transmission System Operators for Electricity as a basis. For each country and phase, we derive representative daily load profiles with hourly resolution obtained by k-medoids clustering. The analysis could unravel the influence of the different measures to the energy consumption and the differences among the four countries. It is observed that the daily peak load is considerably flattened and the total electricity consumption decreases by up to 30% under the circumstances brought about by the COVID-19 restrictions. These demand profiles are useful for the energy planning community, especially when designing future electricity systems with a focus on system resilience and a more digitalised society in terms of working from home.

The effectiveness of extracorporeal shock wave therapy in the treatment of plantar fasciitis is controversial. The objective of the present study was to test whether focused extracorporeal shock wave therapy is effective in relieving chronic heel pain diagnosed as plantar fasciitis.Two hundred and fifty subjects were enrolled in a prospective, multicenter, double-blind, randomized, and placebo-controlled U.S. Food and Drug Administration trial. Subjects were randomized to focused extracorporeal shock wave therapy (0.25 mJ/mm(2)) or placebo intervention, with three sessions of 2000 impulses in weekly intervals. Primary outcomes were both the percentage change of heel pain on the visual analog scale composite score (pain during first steps in the morning, pain with daily activities, and pain with a force meter) and the Roles and Maudsley score at twelve weeks after the last intervention compared with the scores at baseline.Two hundred and forty-six patients (98.4%) were available for intention-to-treat analysis at the twelve-week follow-up. With regard to the first primary end point, the visual analog scale composite score, there was a significant difference (p = 0.0027, one-sided) in the reduction of heel pain in the extracorporeal shock wave therapy group (69.2%) compared with the placebo therapy group (34.5%). Extracorporeal shock wave therapy was also significantly superior to the placebo therapy for the Roles and Maudsley score (p = 0.0006, one-sided). Temporary pain and swelling during and after treatment were the only device-related adverse events observed.The results of the present study provide proof of the clinically relevant effect size of focused extracorporeal shock wave therapy without local anesthesia in the treatment of recalcitrant plantar fasciitis, with success rates between 50% and 65%.Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.

Chronic axonal polyneuropathy is a well-known clinical sequela of excessive alcohol consumption; however, acute axonal polyneuropathy related to alcohol abuse is less well recognized.To describe alcohol-related acute axonal polyneuropathy in 5 chronic alcoholics who developed ascending flaccid tetraparesis and areflexia within 14 days.Case series with clinical, laboratory, electrophysiological, and, in 1 patient, biopsy data.All 5 patients consumed a daily average of 250 g of alcohol, and 4 had lost a substantial amount of weight recently. Additional clinical features included painful paresthesia, myalgia, and glove and stocking-type sensory loss. Repeated cerebrospinal fluid examinations failed to show the marked increase of protein concentration with normal cell count typical of Guillain-Barré syndrome, although the protein level was mildly elevated in 1 patient. Blood laboratory findings were consistent with longstanding alcohol abuse. Compound muscle and sensory nerve action potentials were absent or reduced, while conduction velocities were normal or mildly reduced. Three to 4 weeks after onset, needle electromyography displayed moderate to severe fibrillations and positive sharp waves in addition to normal motor unit potentials, indicating an acute axonal polyneuropathy; this was confirmed by sural nerve biopsy in 1 patient.Excluding other factors, we assume that in these patients the combination of alcohol abuse and malnutrition caused severe acute axonal polyneuropathy. Its distinction from Guillain-Barré syndrome is important because treatment requires balanced diet, vitamin supplementation, and abstinence from alcohol, while immunotherapy may not be indicated.

Context. The simultaneous detection of organic molecules of the form C2HnO, such as ketene (CH2CO), acetaldehyde (CH3CHO), and ethanol (CH3CH2OH), toward early star-forming regions offers hints of a shared chemical history. Several reaction routes have been proposed and experimentally verified under various interstellar conditions to explain the formation pathways involved. Most noticeably, the non-energetic processing of C2H2 ice with OH-radicals and H-atoms was shown to provide formation routes to ketene, acetaldehyde, ethanol, and vinyl alcohol (CH2CHOH) along the H2O formation sequence on grain surfaces in translucent clouds. Aims. In this work, the non-energetic formation scheme is extended with laboratory measurements focusing on the energetic counterpart, induced by cosmic rays penetrating the H2O-rich ice mantle. The focus here is on the H+ radiolysis of interstellar C2H2:H2O ice analogs at 17 K. Methods. Ultra-high vacuum experiments were performed to investigate the 200 keV H+ radiolysis chemistry of predeposited C2H2:H2O ices, both as mixed and layered geometries. Fourier-transform infrared spectroscopy was used to monitor in situ newly formed species as a function of the accumulated energy dose (or H+ fluence). The infrared spectral assignments are further confirmed in isotope labeling experiments using H218O. Results. The energetic processing of C2H2:H2O ice not only results in the formation of (semi-) saturated hydrocarbons (C2H4 and C2H6) and polyynes as well as cumulenes (C4H2 and C4H4), but it also efficiently forms O-bearing COMs, including vinyl alcohol, ketene, acetaldehyde, and ethanol, for which the reaction cross-section and product composition are derived. A clear composition transition of the product, from H-poor to H-rich species, is observed as a function of the accumulated energy dose. Furthermore, the astronomical relevance of the resulting reaction network is discussed.

This study assesses environmental Kuznets curve (EKC) hypothesis corroborating the role of scale, composite, and technology effects in OECD countries. To this end, we analyze the panel time series data from 1980 to 2017 using cross-sectional-autoregressive distributed lags (CS-ARDL). We document that economic growth and carbon emissions follow a U-shaped relationship, contrary to the EKC hypothesis, which our analysis attributes to the substantial contributions of the industrial, manufacturing, and service sectors to GDP. Technological progress has a somewhat marginal impact in reducing carbon emissions through energy efficiency but is unable to validate the existence of EKC hypothesis.

The security of energy supply has again become a similarly hot topic as it was during the oil crises in the 1970s, not least due to the recent historical oil price peaks. In this paper, we analyze the energy security situation of the G7 countries using a statistical risk indicator and empirical energy data for the years 1978 through 2007. We find that Germany's energy supply risk has risen substantially since the oil price crises of the 1970s, whereas France has managed to reduce its risk dramatically, most notably through the deployment of nuclear power plants. As a result of the legally stipulated nuclear phase-out, Germany's supply risk can be expected to rise further and to approach the level of Italy. Due to its resource poverty, Italy has by far the highest energy supply risk among G7 countries.

Ethanolic and aqueous extracts of the “bee glue” Propolis exhibit antioxidative properties and are used as antiinflammatory drugs in folk medicine. In order to standardize the principle activities of prominent components of these extracts, simple biochemical tests have been introduced in the preceding paper. These activity tests prove the high antioxidative and inhibitory capacities of aqueous and ethanolic extracts of propolis in vitro. In the present communication we report on experiments documenting photodynamic quenching properties of these extracts. Using riboflavin, rose bengal or hematoporphyrin as photoactivators and ketomethyl-thiobutyric acid or crocin as indicators, the protective functions of propolis preparations can be demonstrated. The results indicate that the aqueous extracts are more active than the corresponding ethanolic preparation.