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If femoral blood is not available at autopsy, toxicological analyses, in particular blood ethanol measurements, are carried out on cardiac blood. This is known to be subject to major redistribution. We aimed to determine whether subclavian blood can be equated with a peripheral blood sample and could be used if femoral blood is not available. The study was based on 50 medicolegal autopsies in which we compared ethanol concentrations between subclavian blood, the different heart blood compartments (right and left cardiac blood), and femoral blood. Mechanisms that could lead to variations in concentration, i.e., postmortem redistribution and/or endogenous production, were also taken into account in interpreting the results. Ethanol concentrations were determined by headspace gas chromatography with a flame ionization detector. In each case, we recorded the circumstances of death, resuscitation attempts if any, degree of putrefaction, chest or abdominal trauma, and/or inhalation of gastric fluid in the airways. Ethanol concentrations in subclavian blood were found to be close to those in peripheral blood (p = 0.948) and were not influenced by the degree of putrefaction (r = 0.017, p = 0.904), gastric ethanol concentration (r = -0.011, p = 0.940), inhalation of gastric contents in the airways (p = 0.461), or cardiac resuscitation attempts (p = 0.368). We discuss the possible explanations for these findings and stress the value of sampling subclavian blood when femoral blood is not obtainable at autopsy.

This article presents a model of development, civil war and climate change. There are multiple interactions. Economic growth reduces the probability of civil war and the vulnerability to climate change. Climate change increases the probability of civil war. The impacts of climate change, civil war and civil war in the neighbouring countries reduce economic growth. The model has two potential poverty traps – one is climate-change-induced and one is civil-war-induced – and the two poverty traps may reinforce one another. The model is calibrated to sub-Saharan Africa and a double Monte Carlo analysis is conducted in order to account for both parameter uncertainty and stochasticity. Although the IPCC Special Report on Emission Scenarios (SRES) is used as the baseline, thus assuming rapid economic growth in Africa and convergence of African living standards to the rest of the world, the impacts of civil war and climate change (ignored in SRES) are sufficiently strong to keep a number of countries in Africa in deep poverty with a high probability.

Abstract The growth and development of maize (Zea mays L.) largely depends on its nutrient uptake through the root. Hence, studying its growth, response, and associated metabolic reprogramming to stress conditions is becoming an important research direction. A genome-scale metabolic model (GSM) for the maize root was developed to study its metabolic reprogramming under nitrogen stress conditions. The model was reconstructed based on the available information from KEGG, UniProt, and MaizeCyc. Transcriptomics data derived from the roots of hydroponically grown maize plants were used to incorporate regulatory constraints in the model and simulate nitrogen-non-limiting (N+) and nitrogen-deficient (N−) condition. Model-predicted flux-sum variability analysis achieved 70% accuracy compared with the experimental change of metabolite levels. In addition to predicting important metabolic reprogramming in central carbon, fatty acid, amino acid, and other secondary metabolism, maize root GSM predicted several metabolites (l-methionine, l-asparagine, l-lysine, cholesterol, and l-pipecolate) playing a regulatory role in the root biomass growth. Furthermore, this study revealed eight phosphatidylcholine and phosphatidylglycerol metabolites which, even though not coupled with biomass production, played a key role in the increased biomass production under N-deficient conditions. Overall, the omics-integrated GSM provides a promising tool to facilitate stress condition analysis for maize root and engineer better stress-tolerant maize genotypes.

Le présent article pose comme hypothèse principale qu’il existe une spécificité insulaire en matière de changement climatique, tant dans le domaine géopolitique que dans le domaine économique. A la différence des pays continentaux, le changement climatique est un facteur de structuration des États insulaires. Créée en 1990, 2 ans après que le GIEC commence ses travaux, l’Alliance des Petits États insulaires (AOSIS) s’est beaucoup investie dans la ratification du Protocole de Kyoto. Ces derniers se considèrent en effet comme les premières et principales victimes du changement climatique dont le coût pour leurs économies sera nettement plus élevé que celui supporté par les pays continentaux. Aux coûts directs, résultant de l’aléa naturel, notamment la montée du niveau de la mer et l’érosion du littoral qui lui est associée, se surimposeront des coûts induits par les mesures prises au niveau international pour lutter contre le changement climatique. Ces mesures conduisent à remettre la distance géographique au cœur de la logique de localisation des entreprises. La limitation des déplacements aériens et maritimes au long cours qui en résultera devrait entraîner une réduction de la demande mondiale pour les produits et services touristiques insulaires, suivie d’une concurrence exacerbée entre les îles pour attirer cette demande réduite. On assistera alors à la marginalisation des économies insulaires ne pouvant se positionner sur des marchés de niche aux échelles mondiales et régionales avec pour principaux corollaires l’exode rural et la migration internationale. Les recompositions économiques et territoriales qui s’annoncent sont des processus durables qui s’inscrivent dans le temps long. En revanche, le sommet de Copenhague a montré que la structuration politique des États insulaires sur la scène internationale est un processus fragile. L’AOSIS est sortie éclatée de ce sommet. L’avenir des îles est définitivement sous contrainte du changement climatique et il s’annonce bien sombre.

To review the available evidence that examines the association between climatic and agricultural land use factors and the risks of enteric zoonoses in humans and consider information needs and possible pathways of intervention.The electronic databases PubMed, Web of Science and Embase and government websites were searched systematically for published literature that investigated the association of climatic and/or agricultural exposures with the incidence of the four most common enteric zoonotic diseases in New Zealand (campylobacteriosis, salmonellosis, cryptosporidiosis and giardiasis). Results The 16 studies in the review demonstrated significant associations between climate, agricultural land use and enteric disease occurrence. The evidence suggests that enteric disease risk from environmental reservoirs is pathogen specific. In some rural regions, environmental pathogen load is considerable, with multiple opportunities for zoonotic transmission.Enteric disease occurrence in NZ is associated with climate variability and agricultural land use. However, these relationships interact with demographic factors to influence disease patterns.Improved understanding of how environmental and social factors interact can inform effective public health interventions under scenarios of projected environmental change.

Abstract During successive industrial revolutions, the objective has not only been for industry to improve and satisfy its direct needs, it has also been to improve society’s standard of living and make life easier for the consumer. Therefore, economic growth should always go hand in hand with each industrial revolution. The medical industry, energy conservation and, in particular, production technologies will be transformed through new value chain models. Globalization, urbanization, demographic change and energy transformation are the transforming forces estimating the technological impetus for a better identification of solutions for a world on the move. In recent years, successive revolutions have made remarkable contributions to a person’s quality of life, safety, industrial economy, comfort and health. This work aims at improving the energy consumption of buildings. To achieve this goal, we have created a Digital Twin that accurately reflects the behavior and characteristics of a future or existing building. To reproduce a copy of the future or existing building, we chose to use the Autodesk REVIT solution to meet several constraints. These have a significant influence on the energy behavior of the building.

To help policymakers form a judgment on inflation risks and the required monetary policy stance the OECD has developed an analytical framework based on a set of 'eclectic' Phillips curves estimated for the two largest OECD economies, the United States and the euro area, which is presented in this paper. This framework is used in the preparation of the Economic Outlook to explain recent developments in core inflation, excluding food and energy, based on developments in measures of economic slack (the output gap), spill-over effects from energy prices onto core inflation and lagged responses to past inflation via expectations formation. The fact that the knock-on effects from energy shocks onto core inflation appear small in comparison with the 1970s can be explained by the secular fall in energy intensity, a low and stable rate of 'mean inflation' -- to which observed inflation reverts after a shock has worked its way through -- and persistent slack in the aftermath of the bursting of the dotcom bubble.