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Relation of Height, Body Mass, Energy Intake, and Physical Activity to Risk of Renal Cell Carcinoma: Results from the Netherlands Cohort Study

Authors: Dijk, B.A.C. van; Schouten, L.J.; Kiemeney, L.A.L.M.; Goldbohm, R.A.; Brandt, P.A. van den;

Relation of Height, Body Mass, Energy Intake, and Physical Activity to Risk of Renal Cell Carcinoma: Results from the Netherlands Cohort Study

Abstract

Data from the Netherlands Cohort Study on Diet and Cancer were used to investigate the association between anthropometry, energy intake, and physical activity and risk of renal cell carcinoma (RCC). The Netherlands Cohort Study on Diet and Cancer consists of 120,852 men and women aged 55-69 years who completed a self-administered questionnaire at baseline (1986). A case-cohort approach was used. After 9.3 years of follow-up, 275 microscopically confirmed incident cases were available for analysis. Incidence rate ratios for RCC were estimated using Cox proportional hazards models. Height was associated with RCC risk only in women (per 5-cm increment, rate ratio (RR) = 1.23, 95% confidence interval (CI): 1.03, 1.46). Body mass index (weight (kg)/height (m)(2)) was associated with increased risk of RCC (per 1-kg/m(2 )increment, RR = 1.07, 95% CI: 1.02, 1.12) for men and women, as was gain in body mass index from age 20 years to baseline (per 1-kg/m(2 )increment, RR = 1.06, 95% CI: 1.01, 1.10). Energy intake was not related to RCC risk, while a possible protective effect was observed for physical activity in men. These results suggest that body mass index and gain in body mass index since age 20 are associated with increased risk of RCC.

Country
Netherlands
Keywords

Leisure activities, caloric intake, Male, data analysis, kidney carcinoma, physical activity, Weight Gain, Body Mass Index, Energy use, UMCN 1.5: Interventional oncology, Risk Factors, Prospective Studies, Body mass index, Cancer, Netherlands, Recreational activity, anthropometry, Kidney carcinoma, Anthropometry, exercise, Incidence, adult, article, lipid peroxidation, weight gain, Middle Aged, cohort analysis, Kidney Neoplasms, aged, body fat, female, Body mass, risk factor, Body fat, Health, body height, Female, Cohort analysis, EBP 1: Determinants in Health and Disease, Human, Adult, Lipid peroxidation, Data analysis, Food and Chemical Risk Analysis, Major clinical study, Motor Activity, energy use, male, cancer, Humans, human, Exercise, Carcinoma, Renal Cell, Carcinoma, renal cell, Leisure, Weight gain, Aged, Physical activity, Questionnaire, questionnaire, Carcinoma, Renal Cell, major clinical study, body mass, Body Height, renal cell, recreational activity, Body height, leisure, incidence, Energy intake, Risk factor, Caloric intake, Kidney neoplasms, Energy Intake, Follow-Up Studies

  • BIP!
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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    93
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
93
Top 10%
Top 10%
Top 10%
bronze