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description Publicationkeyboard_double_arrow_right Article , Journal 2019Publisher:Elsevier BV Authors: Argyris Kanellopoulos; Aleksander Banasik; G.D.H. Claassen; Jacqueline M. Bloemhof-Ruwaard;Due to the increasing awareness of climate change, depletion of natural resources, and increasing world population, companies in the agri-food sector need to redesign their existing supply chains and take into account both the economic and environmental impact of their operations. In practice not all the required information is available in advance due to various sources of uncertainty in agri-food supply chains. In this research a multi-objective two-stage stochastic programming model is proposed to analyse and evaluate the economic and environmental impacts to account for uncertainty in agri-food supply chains. A mushroom supply chain in the Netherlands is presented as an illustrative case study. Optimal production planning decisions calculated with a two-stage stochastic programming model are compared with the results of an equivalent deterministic model. The results of the optimizations show that accounting for stochasticity in important model parameters can reduce the difference between expected and realized economic performance by approximately 4% on average. Moreover, this paper demonstrates that including stochastic model parameters can reduce the environmental impact without compromising the current economic performance. Given the assumptions in the setup of the case study and the available information, it is concluded that applying a 2-stage stochastic programming approach for production planning decisions can lead to improved economic and environmental performance in an agri-food supply chain. New findings in real-life case studies are needed to get profound insights and understanding on the impact of uncertainty on production planning decisions in sustainable agri-food supply chains.
Journal of Cleaner P... arrow_drop_down Journal of Cleaner ProductionArticle . 2019Data sources: DANS (Data Archiving and Networked Services)Journal of Cleaner ProductionArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jclepro.2019.01.153&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 60 citations 60 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert Journal of Cleaner P... arrow_drop_down Journal of Cleaner ProductionArticle . 2019Data sources: DANS (Data Archiving and Networked Services)Journal of Cleaner ProductionArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jclepro.2019.01.153&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2016Publisher:Elsevier BV Authors: Marc Spiller;pmid: 27390059
Sustainability is commonly assessed along environmental, societal, economic and technological dimensions. A crucial aspect of sustainability is that inter-generational equality must be ensured. This requires that sustainability is attained in the here and now as well as into the future. Therefore, what is perceived as 'sustainable' changes as a function of societal opinion and technological and scientific progress. A concept that describes the ability of systems to change is adaptive capacity. Literature suggests that the ability of systems to adapt is an integral part of sustainable development. This paper demonstrates that indicators measuring adaptive capacity are underrepresented in current urban water sustainability studies. Furthermore, it is discussed under which sustainability dimensions adaptive capacity indicators are lacking and why. Of the >90 indicators analysed, only nine are adaptive capacity indicators, of which six are socio-cultural, two technological, one economical and none environmental. This infrequent use of adaptive capacity indicators in sustainability assessments led to the conclusion that the challenge of dynamic and uncertain urban water systems is, with the exception of the socio-cultural dimension, not yet sufficiently reflected in the application of urban water sustainability indicators. This raises concerns about the progress towards urban water systems that can transform as a response variation and change. Therefore, research should focus on developing methods and indicators that can define, evaluate and quantify adaptive capacity under the economic, environmental and technical dimension of sustainability. Furthermore, it should be evaluated whether sustainability frameworks that focus on the control processes of urban water systems are more suitable for measuring adaptive capacity, than the assessments along environmental, economic, socio-cultural and technological dimensions.
The Science of The T... arrow_drop_down The Science of The Total EnvironmentArticle . 2016Data sources: DANS (Data Archiving and Networked Services)The Science of The Total EnvironmentArticle . 2016 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.scitotenv.2016.06.088&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 36 citations 36 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert The Science of The T... arrow_drop_down The Science of The Total EnvironmentArticle . 2016Data sources: DANS (Data Archiving and Networked Services)The Science of The Total EnvironmentArticle . 2016 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.scitotenv.2016.06.088&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2021 ItalyPublisher:Hindawi Limited Authors: Yagmur Atak; C. Ozgur Colpan; Adolfo Iulianelli;doi: 10.1002/er.7186
The most widely used process for hydrogen production is steam methane reforming. It can be carried out using a membrane reactor in which simultaneous hydrogen production and purification occur. Mathematical modeling of these reactors plays a key role in the selection of the design and operating parameters that yield high performance for the reactor. This review study discusses, synthesizes, and compares different mathematical modeling studies on the packed bed membrane reactors for hydrogen production from methane found in the literature. Different approaches used in these modeling studies for the hydrogen permeation steps, reaction kinetic expressions, phases involved (pseudo-homogeneous and heterogeneous), and spatial dimensions (one, two, and three dimensional) are given.
CNR ExploRA arrow_drop_down International Journal of Energy ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/er.7186&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert CNR ExploRA arrow_drop_down International Journal of Energy ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/er.7186&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2015Publisher:Elsevier BV Authors: Hilde M. Toonen; H.J. Lindeboom;European consumers are willing to pay more for “green” electricity, as they highly value renewable energy sources for the contribution to combating climate change. There is a push for getting higher levels of sustainability, leading to a differentiation of Europe‘s electricity market. In this differentiation, the large potential of wind energy is recognized. More specifically, North Sea countries prefer to plan wind arrays (far) out at sea. This article offers a review of the main arguments for offshore wind energy, described in comparison with its onshore counterpart. It is stated that offshore wind farms (OWFs) generate “dark green” electricity as they mitigate greenhouse gas emissions and contribute to the protection of (some) marine life. Applying an informational governance framework, this article further assesses whether this dark green message has been exploited through further differentiation of the electricity market, and provides an analysis of why this is not (yet) the case. It is concluded that the dominant discourse in onshore wind power development hinders a favorable ecological differentiation toward offshore wind power.
Renewable and Sustai... arrow_drop_down Renewable and Sustainable Energy ReviewsArticle . 2015Data sources: DANS (Data Archiving and Networked Services)Renewable and Sustainable Energy ReviewsArticle . 2015 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.rser.2014.10.043&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 16 citations 16 popularity Average influence Top 10% impulse Top 10% Powered by BIP!
more_vert Renewable and Sustai... arrow_drop_down Renewable and Sustainable Energy ReviewsArticle . 2015Data sources: DANS (Data Archiving and Networked Services)Renewable and Sustainable Energy ReviewsArticle . 2015 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.rser.2014.10.043&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object , Article 2011 ItalyPublisher:IEEE Authors: Aliberti; Massimo;Intention of this work is to investigate the opportunity and feasibility of energy efficient networking in Home and Building automation protocols. Wired HBAS have traditionally devoted a relatively little attention to this point, especially if compared to wireless networks. This paper will try to address the issue by evaluating the introduction of power state switching in a real scenario and proposing the concept of functional and spatial adjacency among packets.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/icce.2011.5722802&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!
visibility 1visibility views 1 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/icce.2011.5722802&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2019 PortugalPublisher:Elsevier BV Funded by:FCT | Laboratory for Robotics a..., FCT | SusCity, FCT | Associate Laboratory of ...FCT| Laboratory for Robotics and Engineering Systems ,FCT| SusCity ,FCT| Associate Laboratory of Energy, Transports and AeronauticsRoberto A. Varella; Gonçalo Duarte; Gonçalo Duarte; Marta V. Faria; Patrícia Baptista; Tiago L. Farias;Abstract This work assesses the impacts of aggressive driving behavior on pollutants emissions and energy consumption at a city level. Furthermore, it performs an economic analysis considering the potential avoided emissions and fuel savings and discusses potential policy measures to address this topic. The results showed that aggressive driving significantly impacts energy consumption and emissions, with energy consumption increasing by more than ∼200% and emissions by 330% for aggressive driving compared to non-aggressive driving (in MJ/km and in g/km, respectively). This increment was found to be even higher for diesel vehicles than for gasoline vehicles. On the contrary, gasoline vehicles showed higher percentages of increase for most emissions (CO, NOx and NO). Results also revealed that aggressive driving impacts are higher for local streets when examining the city level. Moreover, the economic analysis showed that significant cost reductions may be achieved by avoiding aggressive driving, reaching up to 52.5 k€ on a daily basis. In conclusion, this study is of particular relevance to policy makers and urban planners, enabling to obtain a comprehensive overview of the impacts of aggressive driving behaviors at a city level and providing new insights to perform further developments and to assess the feasibility of the implementation of policy measures.
Repositório Científi... arrow_drop_down Repositório Científico do Instituto Politécnico de LisboaArticle . 2019Energy Research & Social ScienceArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.erss.2018.09.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 25 citations 25 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
visibility 88visibility views 88 download downloads 52 Powered bymore_vert Repositório Científi... arrow_drop_down Repositório Científico do Instituto Politécnico de LisboaArticle . 2019Energy Research & Social ScienceArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.erss.2018.09.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2013Publisher:Elsevier BV Authors: André Faaij; Veronika Dornburg; Ric Hoefnagels; Martin Banse;Biomass is considered one of the most important options in the transition to a sustainable energy system with reduced greenhouse gas (GHG) emissions and increased security of enegry supply. In order to facilitate this transition with targeted policies and implementation strategies, it is of vital importance to understand the economic benefits, uncertainties and risks of this transition. This article presents a quantification of the economic impacts on value added, employment shares and the trade balance as well as required biomass and avoided primary energy and greenhouse gases related to large scale biomass deployment on a country level (the Netherlands) for different future scenarios to 2030. This is done by using the macro-economic computable general equilibrium (CGE) model LEITAP, capable of quantifying direct and indirect effects of a bio-based economy combined with a spread sheet tool to address underlying technological details. Although the combined approach has limitations, the results of the projections show that substitution of fossil energy carriers by biomass, could have positive economic effects, as well as reducing GHG emissions and fossil energy requirement. Key factors to achieve these targets are enhanced technological development and the import of sustainable biomass resources to the Netherlands. (C) 2013 Elsevier Ltd. All rights reserved.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.enpol.2013.04.026&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 32 citations 32 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.enpol.2013.04.026&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2013Publisher:Ovid Technologies (Wolters Kluwer Health) Authors: Mark P. Jensen; Johannes Vlaeyen; Warren R. Nielson; Petra A. Karsdorp;pmid: 23247005
Activity pacing (AP) is a concept that is central to many chronic pain theories and treatments, yet there remains confusion regarding its definition and effects.To review the current knowledge concerning AP and integrate this knowledge in a manner that allows for a clear definition and useful directions for future research.A narrative review of the major theoretical approaches to AP and of the empirical evidence regarding the effects of AP interventions, followed by an integrative discussion.The concept of AP is derived from 2 main traditions: operant and energy conservation. Although there are common elements across these traditions, significant conceptual and practical differences exist, which has led to confusion. Little empirical evidence exists concerning the efficacy of AP as a treatment for chronic pain.Future research on AP should be based on a clear theoretical foundation, consider the context in which the AP behavior occurs and the type of pacing problem ("underactivity" vs. "overactivity"), and should examine the impact of AP treatment on multiple clinical outcomes. We provide a provisional definition of AP and specific recommendations that we believe will move the field forward.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/ajp.0b013e3182608561&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 115 citations 115 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/ajp.0b013e3182608561&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2014Publisher:Wiley Authors: N.A. Hardt; Remko M. Boom; A.J. van der Goot; Anja E.M. Janssen;doi: 10.1002/bit.25197
pmid: 24474643
ABSTRACTEnzymatic wheat gluten hydrolysis at high solid concentrations is advantageous from an environmental and economic point of view. However, increased wheat gluten concentrations result in a concentration effect with a decreased hydrolysis rate at constant enzyme‐to‐substrate ratios and a decreased maximum attainable degree of hydrolysis (DH%). We here identified the underlying factors causing the concentration effect. Wheat gluten was hydrolyzed at solid concentrations from 4.4% to 70%. The decreased hydrolysis rate was present at all solid concentrations and at any time of the reaction. Mass transfer limitations, enzyme inhibition and water activity were shown to not cause this hydrolysis rate limitation up to 50% solids. However, the hydrolysis rate limitation can be, at least partly, explained by a second‐order enzyme inactivation process. Furthermore, mass transfer impeded the hydrolysis above 60% solids. Addition of enzyme after 24 h at high solid concentrations scarcely increased the DH%, suggesting that the maximum attainable DH% decreases at high solid concentrations. Reduced enzyme activities caused by low water activities can explain this DH% limitation. Finally, a possible influence of the plastein reaction on the DH% limitation is discussed. Biotechnol. Bioeng. 2014;111: 1304–1312. © 2014 Wiley Periodicals, Inc.
Biotechnology and Bi... arrow_drop_down Biotechnology and BioengineeringArticle . 2014Data sources: DANS (Data Archiving and Networked Services)Biotechnology and BioengineeringArticle . 2014 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/bit.25197&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 11 citations 11 popularity Average influence Average impulse Top 10% Powered by BIP!
more_vert Biotechnology and Bi... arrow_drop_down Biotechnology and BioengineeringArticle . 2014Data sources: DANS (Data Archiving and Networked Services)Biotechnology and BioengineeringArticle . 2014 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/bit.25197&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2014Publisher:Elsevier BV A. Charlotte P. Sewing; Viola Caretti; Tonny Lagerweij; Pepijn Schellen; Marc H.A. Jansen; Dannis G. van Vuurden; Sander Idema; Carla F.M. Molthoff; W. Peter Vandertop; Gertjan J.L. Kaspers; David P. Noske; Esther Hulleman;pmid: 25263805
Systemic delivery of therapeutic agents remains ineffective against diffuse intrinsic pontine glioma (DIPG), possibly due to an intact blood-brain-barrier (BBB) and to dose-limiting toxicity of systemic chemotherapeutic agents. Convection-enhanced delivery (CED) into the brainstem may provide an effective local delivery alternative for DIPG patients.The aim of this study is to develop a method to perform CED into the murine brainstem and to test this method using the chemotherapeutic agent carmustine (BiCNU). To this end, a newly designed murine CED catheter was tested in vitro and in vivo. After determination of safety and distribution, mice bearing VUMC-DIPG-3 and E98FM-DIPG brainstem tumors were treated with carmustine dissolved in DW 5% or carmustine dissolved in 10% ethanol.Our results show that CED into the murine brainstem is feasible and well tolerated by mice with and without brainstem tumors. CED of carmustine dissolved in 5% DW increased median survival of mice with VUMC-DIPG-3 and E98FM-DIPG tumors with 35% and 25% respectively. Dissolving carmustine in 10% ethanol further improved survival to 45% in mice with E98FM-DIPG tumors.Since genetically engineered and primary DIPG models are currently only available in mice, murine CED studies have clear advantages over CED studies in other animals.CED in the murine brainstem can be performed safely, is well tolerated and can be used to study efficacy of chemotherapeutic agents orthotopically. These results set the foundation for more CED studies in murine DIPG models.
Journal of Neuroscie... arrow_drop_down Journal of Neuroscience MethodsArticle . 2014Data sources: DANS (Data Archiving and Networked Services)Journal of Neuroscience MethodsArticle . 2014 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jneumeth.2014.09.020&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 23 citations 23 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Journal of Neuroscie... arrow_drop_down Journal of Neuroscience MethodsArticle . 2014Data sources: DANS (Data Archiving and Networked Services)Journal of Neuroscience MethodsArticle . 2014 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jneumeth.2014.09.020&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article , Journal 2019Publisher:Elsevier BV Authors: Argyris Kanellopoulos; Aleksander Banasik; G.D.H. Claassen; Jacqueline M. Bloemhof-Ruwaard;Due to the increasing awareness of climate change, depletion of natural resources, and increasing world population, companies in the agri-food sector need to redesign their existing supply chains and take into account both the economic and environmental impact of their operations. In practice not all the required information is available in advance due to various sources of uncertainty in agri-food supply chains. In this research a multi-objective two-stage stochastic programming model is proposed to analyse and evaluate the economic and environmental impacts to account for uncertainty in agri-food supply chains. A mushroom supply chain in the Netherlands is presented as an illustrative case study. Optimal production planning decisions calculated with a two-stage stochastic programming model are compared with the results of an equivalent deterministic model. The results of the optimizations show that accounting for stochasticity in important model parameters can reduce the difference between expected and realized economic performance by approximately 4% on average. Moreover, this paper demonstrates that including stochastic model parameters can reduce the environmental impact without compromising the current economic performance. Given the assumptions in the setup of the case study and the available information, it is concluded that applying a 2-stage stochastic programming approach for production planning decisions can lead to improved economic and environmental performance in an agri-food supply chain. New findings in real-life case studies are needed to get profound insights and understanding on the impact of uncertainty on production planning decisions in sustainable agri-food supply chains.
Journal of Cleaner P... arrow_drop_down Journal of Cleaner ProductionArticle . 2019Data sources: DANS (Data Archiving and Networked Services)Journal of Cleaner ProductionArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jclepro.2019.01.153&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 60 citations 60 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert Journal of Cleaner P... arrow_drop_down Journal of Cleaner ProductionArticle . 2019Data sources: DANS (Data Archiving and Networked Services)Journal of Cleaner ProductionArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jclepro.2019.01.153&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2016Publisher:Elsevier BV Authors: Marc Spiller;pmid: 27390059
Sustainability is commonly assessed along environmental, societal, economic and technological dimensions. A crucial aspect of sustainability is that inter-generational equality must be ensured. This requires that sustainability is attained in the here and now as well as into the future. Therefore, what is perceived as 'sustainable' changes as a function of societal opinion and technological and scientific progress. A concept that describes the ability of systems to change is adaptive capacity. Literature suggests that the ability of systems to adapt is an integral part of sustainable development. This paper demonstrates that indicators measuring adaptive capacity are underrepresented in current urban water sustainability studies. Furthermore, it is discussed under which sustainability dimensions adaptive capacity indicators are lacking and why. Of the >90 indicators analysed, only nine are adaptive capacity indicators, of which six are socio-cultural, two technological, one economical and none environmental. This infrequent use of adaptive capacity indicators in sustainability assessments led to the conclusion that the challenge of dynamic and uncertain urban water systems is, with the exception of the socio-cultural dimension, not yet sufficiently reflected in the application of urban water sustainability indicators. This raises concerns about the progress towards urban water systems that can transform as a response variation and change. Therefore, research should focus on developing methods and indicators that can define, evaluate and quantify adaptive capacity under the economic, environmental and technical dimension of sustainability. Furthermore, it should be evaluated whether sustainability frameworks that focus on the control processes of urban water systems are more suitable for measuring adaptive capacity, than the assessments along environmental, economic, socio-cultural and technological dimensions.
The Science of The T... arrow_drop_down The Science of The Total EnvironmentArticle . 2016Data sources: DANS (Data Archiving and Networked Services)The Science of The Total EnvironmentArticle . 2016 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.scitotenv.2016.06.088&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 36 citations 36 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert The Science of The T... arrow_drop_down The Science of The Total EnvironmentArticle . 2016Data sources: DANS (Data Archiving and Networked Services)The Science of The Total EnvironmentArticle . 2016 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.scitotenv.2016.06.088&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2021 ItalyPublisher:Hindawi Limited Authors: Yagmur Atak; C. Ozgur Colpan; Adolfo Iulianelli;doi: 10.1002/er.7186
The most widely used process for hydrogen production is steam methane reforming. It can be carried out using a membrane reactor in which simultaneous hydrogen production and purification occur. Mathematical modeling of these reactors plays a key role in the selection of the design and operating parameters that yield high performance for the reactor. This review study discusses, synthesizes, and compares different mathematical modeling studies on the packed bed membrane reactors for hydrogen production from methane found in the literature. Different approaches used in these modeling studies for the hydrogen permeation steps, reaction kinetic expressions, phases involved (pseudo-homogeneous and heterogeneous), and spatial dimensions (one, two, and three dimensional) are given.
CNR ExploRA arrow_drop_down International Journal of Energy ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/er.7186&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert CNR ExploRA arrow_drop_down International Journal of Energy ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/er.7186&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2015Publisher:Elsevier BV Authors: Hilde M. Toonen; H.J. Lindeboom;European consumers are willing to pay more for “green” electricity, as they highly value renewable energy sources for the contribution to combating climate change. There is a push for getting higher levels of sustainability, leading to a differentiation of Europe‘s electricity market. In this differentiation, the large potential of wind energy is recognized. More specifically, North Sea countries prefer to plan wind arrays (far) out at sea. This article offers a review of the main arguments for offshore wind energy, described in comparison with its onshore counterpart. It is stated that offshore wind farms (OWFs) generate “dark green” electricity as they mitigate greenhouse gas emissions and contribute to the protection of (some) marine life. Applying an informational governance framework, this article further assesses whether this dark green message has been exploited through further differentiation of the electricity market, and provides an analysis of why this is not (yet) the case. It is concluded that the dominant discourse in onshore wind power development hinders a favorable ecological differentiation toward offshore wind power.
Renewable and Sustai... arrow_drop_down Renewable and Sustainable Energy ReviewsArticle . 2015Data sources: DANS (Data Archiving and Networked Services)Renewable and Sustainable Energy ReviewsArticle . 2015 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.rser.2014.10.043&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 16 citations 16 popularity Average influence Top 10% impulse Top 10% Powered by BIP!
more_vert Renewable and Sustai... arrow_drop_down Renewable and Sustainable Energy ReviewsArticle . 2015Data sources: DANS (Data Archiving and Networked Services)Renewable and Sustainable Energy ReviewsArticle . 2015 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.rser.2014.10.043&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object , Article 2011 ItalyPublisher:IEEE Authors: Aliberti; Massimo;Intention of this work is to investigate the opportunity and feasibility of energy efficient networking in Home and Building automation protocols. Wired HBAS have traditionally devoted a relatively little attention to this point, especially if compared to wireless networks. This paper will try to address the issue by evaluating the introduction of power state switching in a real scenario and proposing the concept of functional and spatial adjacency among packets.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/icce.2011.5722802&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!
visibility 1visibility views 1 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/icce.2011.5722802&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2019 PortugalPublisher:Elsevier BV Funded by:FCT | Laboratory for Robotics a..., FCT | SusCity, FCT | Associate Laboratory of ...FCT| Laboratory for Robotics and Engineering Systems ,FCT| SusCity ,FCT| Associate Laboratory of Energy, Transports and AeronauticsRoberto A. Varella; Gonçalo Duarte; Gonçalo Duarte; Marta V. Faria; Patrícia Baptista; Tiago L. Farias;Abstract This work assesses the impacts of aggressive driving behavior on pollutants emissions and energy consumption at a city level. Furthermore, it performs an economic analysis considering the potential avoided emissions and fuel savings and discusses potential policy measures to address this topic. The results showed that aggressive driving significantly impacts energy consumption and emissions, with energy consumption increasing by more than ∼200% and emissions by 330% for aggressive driving compared to non-aggressive driving (in MJ/km and in g/km, respectively). This increment was found to be even higher for diesel vehicles than for gasoline vehicles. On the contrary, gasoline vehicles showed higher percentages of increase for most emissions (CO, NOx and NO). Results also revealed that aggressive driving impacts are higher for local streets when examining the city level. Moreover, the economic analysis showed that significant cost reductions may be achieved by avoiding aggressive driving, reaching up to 52.5 k€ on a daily basis. In conclusion, this study is of particular relevance to policy makers and urban planners, enabling to obtain a comprehensive overview of the impacts of aggressive driving behaviors at a city level and providing new insights to perform further developments and to assess the feasibility of the implementation of policy measures.
Repositório Científi... arrow_drop_down Repositório Científico do Instituto Politécnico de LisboaArticle . 2019Energy Research & Social ScienceArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.erss.2018.09.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 25 citations 25 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
visibility 88visibility views 88 download downloads 52 Powered bymore_vert Repositório Científi... arrow_drop_down Repositório Científico do Instituto Politécnico de LisboaArticle . 2019Energy Research & Social ScienceArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.erss.2018.09.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2013Publisher:Elsevier BV Authors: André Faaij; Veronika Dornburg; Ric Hoefnagels; Martin Banse;Biomass is considered one of the most important options in the transition to a sustainable energy system with reduced greenhouse gas (GHG) emissions and increased security of enegry supply. In order to facilitate this transition with targeted policies and implementation strategies, it is of vital importance to understand the economic benefits, uncertainties and risks of this transition. This article presents a quantification of the economic impacts on value added, employment shares and the trade balance as well as required biomass and avoided primary energy and greenhouse gases related to large scale biomass deployment on a country level (the Netherlands) for different future scenarios to 2030. This is done by using the macro-economic computable general equilibrium (CGE) model LEITAP, capable of quantifying direct and indirect effects of a bio-based economy combined with a spread sheet tool to address underlying technological details. Although the combined approach has limitations, the results of the projections show that substitution of fossil energy carriers by biomass, could have positive economic effects, as well as reducing GHG emissions and fossil energy requirement. Key factors to achieve these targets are enhanced technological development and the import of sustainable biomass resources to the Netherlands. (C) 2013 Elsevier Ltd. All rights reserved.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.enpol.2013.04.026&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 32 citations 32 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.enpol.2013.04.026&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2013Publisher:Ovid Technologies (Wolters Kluwer Health) Authors: Mark P. Jensen; Johannes Vlaeyen; Warren R. Nielson; Petra A. Karsdorp;pmid: 23247005
Activity pacing (AP) is a concept that is central to many chronic pain theories and treatments, yet there remains confusion regarding its definition and effects.To review the current knowledge concerning AP and integrate this knowledge in a manner that allows for a clear definition and useful directions for future research.A narrative review of the major theoretical approaches to AP and of the empirical evidence regarding the effects of AP interventions, followed by an integrative discussion.The concept of AP is derived from 2 main traditions: operant and energy conservation. Although there are common elements across these traditions, significant conceptual and practical differences exist, which has led to confusion. Little empirical evidence exists concerning the efficacy of AP as a treatment for chronic pain.Future research on AP should be based on a clear theoretical foundation, consider the context in which the AP behavior occurs and the type of pacing problem ("underactivity" vs. "overactivity"), and should examine the impact of AP treatment on multiple clinical outcomes. We provide a provisional definition of AP and specific recommendations that we believe will move the field forward.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/ajp.0b013e3182608561&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 115 citations 115 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/ajp.0b013e3182608561&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2014Publisher:Wiley Authors: N.A. Hardt; Remko M. Boom; A.J. van der Goot; Anja E.M. Janssen;doi: 10.1002/bit.25197
pmid: 24474643
ABSTRACTEnzymatic wheat gluten hydrolysis at high solid concentrations is advantageous from an environmental and economic point of view. However, increased wheat gluten concentrations result in a concentration effect with a decreased hydrolysis rate at constant enzyme‐to‐substrate ratios and a decreased maximum attainable degree of hydrolysis (DH%). We here identified the underlying factors causing the concentration effect. Wheat gluten was hydrolyzed at solid concentrations from 4.4% to 70%. The decreased hydrolysis rate was present at all solid concentrations and at any time of the reaction. Mass transfer limitations, enzyme inhibition and water activity were shown to not cause this hydrolysis rate limitation up to 50% solids. However, the hydrolysis rate limitation can be, at least partly, explained by a second‐order enzyme inactivation process. Furthermore, mass transfer impeded the hydrolysis above 60% solids. Addition of enzyme after 24 h at high solid concentrations scarcely increased the DH%, suggesting that the maximum attainable DH% decreases at high solid concentrations. Reduced enzyme activities caused by low water activities can explain this DH% limitation. Finally, a possible influence of the plastein reaction on the DH% limitation is discussed. Biotechnol. Bioeng. 2014;111: 1304–1312. © 2014 Wiley Periodicals, Inc.
Biotechnology and Bi... arrow_drop_down Biotechnology and BioengineeringArticle . 2014Data sources: DANS (Data Archiving and Networked Services)Biotechnology and BioengineeringArticle . 2014 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/bit.25197&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 11 citations 11 popularity Average influence Average impulse Top 10% Powered by BIP!
more_vert Biotechnology and Bi... arrow_drop_down Biotechnology and BioengineeringArticle . 2014Data sources: DANS (Data Archiving and Networked Services)Biotechnology and BioengineeringArticle . 2014 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/bit.25197&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2014Publisher:Elsevier BV A. Charlotte P. Sewing; Viola Caretti; Tonny Lagerweij; Pepijn Schellen; Marc H.A. Jansen; Dannis G. van Vuurden; Sander Idema; Carla F.M. Molthoff; W. Peter Vandertop; Gertjan J.L. Kaspers; David P. Noske; Esther Hulleman;pmid: 25263805
Systemic delivery of therapeutic agents remains ineffective against diffuse intrinsic pontine glioma (DIPG), possibly due to an intact blood-brain-barrier (BBB) and to dose-limiting toxicity of systemic chemotherapeutic agents. Convection-enhanced delivery (CED) into the brainstem may provide an effective local delivery alternative for DIPG patients.The aim of this study is to develop a method to perform CED into the murine brainstem and to test this method using the chemotherapeutic agent carmustine (BiCNU). To this end, a newly designed murine CED catheter was tested in vitro and in vivo. After determination of safety and distribution, mice bearing VUMC-DIPG-3 and E98FM-DIPG brainstem tumors were treated with carmustine dissolved in DW 5% or carmustine dissolved in 10% ethanol.Our results show that CED into the murine brainstem is feasible and well tolerated by mice with and without brainstem tumors. CED of carmustine dissolved in 5% DW increased median survival of mice with VUMC-DIPG-3 and E98FM-DIPG tumors with 35% and 25% respectively. Dissolving carmustine in 10% ethanol further improved survival to 45% in mice with E98FM-DIPG tumors.Since genetically engineered and primary DIPG models are currently only available in mice, murine CED studies have clear advantages over CED studies in other animals.CED in the murine brainstem can be performed safely, is well tolerated and can be used to study efficacy of chemotherapeutic agents orthotopically. These results set the foundation for more CED studies in murine DIPG models.
Journal of Neuroscie... arrow_drop_down Journal of Neuroscience MethodsArticle . 2014Data sources: DANS (Data Archiving and Networked Services)Journal of Neuroscience MethodsArticle . 2014 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jneumeth.2014.09.020&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 23 citations 23 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Journal of Neuroscie... arrow_drop_down Journal of Neuroscience MethodsArticle . 2014Data sources: DANS (Data Archiving and Networked Services)Journal of Neuroscience MethodsArticle . 2014 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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