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Investigation into the combined effects of ethanol and cadmium on rat liver and kidneys

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Aug 1990Publisher:Springer Science and Business Media LLCJournal:Archives of Toxicology, volume 64, pages 470-473 (issn: 0340-5761, eissn: 1432-0738,

Authors: C.-J. Estler; J Bischoff; R Böcker; G Hopf; M G Werner;

doi: 10.1007/bf01977629

pmid: 2275604

Investigation into the combined effects of ethanol and cadmium on rat liver and kidneys

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Abstract

To examine the combined hepatotoxic and nephrotoxic effects of cadmium and ethanol, rats maintained on an ethanol containing liquid diet (5% w/w) were given cadmium either acutely (3 x 1 mg/kg IP) or subacutely (about 14 mg/kg/day PO for 6 weeks). Parameters tested were cadmium, zinc and copper contents of blood and various organs, metallothionein (MT) contents, polysome profile of liver and kidneys, serum SDH and GPT levels and creatinine clearance. Ethanol reduced the hepatic MT contents without altering the polysome profile and the zinc and copper contents. Cadmium on the other hand raised the MT contents in liver and kidneys. This effect of cadmium predominated in the combined treatment. Morphological examination and functional tests (SDH, GPT, creatinine clearance) indicate that cadmium does not enhance the toxic effects of ethanol, and vice versa.

Keywords

Brain Chemistry, L-Iditol 2-Dehydrogenase, Ethanol, Body Weight, Alanine Transaminase, Rats, Inbred Strains, Organ Size, Rats, Zinc, Creatinine, Polyribosomes, Protein Biosynthesis, Animals, Female, Kidney Diseases, Metallothionein, Chemical and Drug Induced Liver Injury, Copper, Cadmium

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	17
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average