Ultraviolet radiation (UV radiation) can lead to numerous skin and eye diseases, both immediately and later in life. The most serious consequence is skin cancer. The risk of skin cancer increases, among other things, with increasing UV irradiance and/or with increasing outdoor exposure times. Due to the fact that UV radiation is carcinogenic, protection of the population against harmful UV exposure is an important radiation protection and health objective.In Germany, ozone depletion and climate change can also influence the UV irradiance and outdoor exposure times to such an extent that the UV exposure of the population and thus the skin cancer risk can increase. This is why protection against harmful UV exposure is even more important. Since ozone depletion and climate change can further increase the UV exposure of humans, protection against high UV exposure is even more important. A country's adaptation strategies to the health consequences of ozone depletion and climate change should therefore also include strategies to reduce UV exposure.In this review, the health effects of UV radiation and the risk factors for UV-related skin cancer are first presented. The measurement of UV irradiance and exposure in Germany is explained. The effects of ozone depletion and climate change on UV exposure are then described and measures to protect the population are presented.