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Influence of sorbitol on the rate of ethanol oxidation and on acetaldehyde accumulation in hypo-, hyper- and euthyroid rats

Name: Influence of sorbitol on the rate of ethanol oxidation and on acetaldehyde accumulation in hypo-, hyper- and euthyroid rats
Creator: M Hillbom
Keywords: Male, 0301 basic medicine, 0303 health sciences, 03010203 Proteins/Proteomics, Ethanol, 030102 biochemistry & molecular biology, 030302 biochemistry & molecular biology, Thyroid Gland, Acetaldehyde, Fructose

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Aug 1970Publisher:Elsevier BVJournal:Life Sciences, volume 9, pages 841-846 (issn: 0024-3205,

Authors: M Hillbom;

doi: 10.1016/0024-3205(70)90052-4

pmid: 5478094

Influence of sorbitol on the rate of ethanol oxidation and on acetaldehyde accumulation in hypo-, hyper- and euthyroid rats

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Abstract

Abstract The influence of sorbitol on the rate of oxidation of ethanol and accumulation of acetaldehyde was studied in intact rats pretreated with propyl thiouracil or triiodothyronine. Sorbital inhibited ethanol oxidation by 58 per cent in hypothyroid and by 33 per cent in euthyroid rats but no significant inhibition was observed in hyperthyroid animals. Fructose increased and sorbitol significantly decresed the acetaldehyde level of hepatic venous blood in euthyroid animals given ethanol. The experiments suggested that the higher the oxidation rate of ethanol the higher the initial concentration of acetaldehyde in the hepatic venous blood of intact rats.

Keywords

Male, Ethanol, Thyroid Gland, Acetaldehyde, Fructose, Hyperthyroidism, Rats, Hypothyroidism, Liver, Animals, Sorbitol, Oxidation-Reduction

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