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Influence of sorbitol on the rate of ethanol oxidation and on acetaldehyde accumulation in hypo-, hyper- and euthyroid rats

pmid: 5478094
Abstract The influence of sorbitol on the rate of oxidation of ethanol and accumulation of acetaldehyde was studied in intact rats pretreated with propyl thiouracil or triiodothyronine. Sorbital inhibited ethanol oxidation by 58 per cent in hypothyroid and by 33 per cent in euthyroid rats but no significant inhibition was observed in hyperthyroid animals. Fructose increased and sorbitol significantly decresed the acetaldehyde level of hepatic venous blood in euthyroid animals given ethanol. The experiments suggested that the higher the oxidation rate of ethanol the higher the initial concentration of acetaldehyde in the hepatic venous blood of intact rats.
Male, Ethanol, Thyroid Gland, Acetaldehyde, Fructose, Hyperthyroidism, Rats, Hypothyroidism, Liver, Animals, Sorbitol, Oxidation-Reduction
Male, Ethanol, Thyroid Gland, Acetaldehyde, Fructose, Hyperthyroidism, Rats, Hypothyroidism, Liver, Animals, Sorbitol, Oxidation-Reduction
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