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Protective effect of human epidermal growth factor against the experimental gastric mucosal lesions in rats

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jan 1990Publisher:Elsevier BVJournal:Life Sciences, volume 47, pages 1,031-1,036 (issn: 0024-3205,

Authors: Michiyasu Ushijima; Masafumi Misaki; Yutaka Higashi; Noboru Yata; Teruo Murakami; Tohru Fuwa; Harunobu Amagase;

doi: 10.1016/0024-3205(90)90475-7

pmid: 2233124

Protective effect of human epidermal growth factor against the experimental gastric mucosal lesions in rats

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Abstract

The protective effect of human epidermal growth factor (hEGF) on the gastric mucosal lesions in rats was examined in relation to the immunoreactive concentration of plasma. Human EGF (30 micrograms/kg) was administered intravenously, intraperitoneally or subcutaneously. At different times following the administration of hEGF, rats received acidified ethanol solution to induce an experimental gastric mucosal lesion. Sum of lesion length in the gastric mucosa was used as a lesion index. Human EGF administered parenterally markedly decreased the gastric mucosal lesions in 10 min after administration of necrotizing solution, and 10 to 30 min delay was observed in the development of maximal protective action. Profiles of protective potency against the hEGF dose administered intraperitoneally or subcutaneously 30 min before administration of necrotizing solution revealed that the effective dose of hEGF (ED50) was about 5.2 and 2.6 micrograms/kg, for intraperitoneal and subcutaneous administrations, respectively.

Related Organizations

National Scientific and Technical Research Council
Argentina
Ross University School of Medicine
Barbados
Hiroshima University Hospital
Japan
Hiroshima University Hospital
Japan
Ross University School of Medicine
United States

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Keywords

Male, Dose-Response Relationship, Drug, Epidermal Growth Factor, Ethanol, Drug Administration Routes, Stomach Diseases, Rats, Inbred Strains, Recombinant Proteins, Rats, Gastric Mucosa, Animals

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