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Soporific action of ethanol in mice: Possible role of biogenic amines

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 May 1973Publisher:Elsevier BVJournal:Pharmacology Biochemistry and Behavior, volume 1, pages 271-276 (issn: 0091-3057,

Authors: James H. Merritt; Irving Geller; W. Calhoun; Jack E. Wallace; Kenneth Blum;

doi: 10.1016/0091-3057(73)90116-0

pmid: 4272868

Soporific action of ethanol in mice: Possible role of biogenic amines

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Abstract

Abstract Ethanol-induced sleep time was measured in mice after administration of L-3,4-dihydroxyphenylalanine (L-DOPA), L-tryptophan (L-TP), DL-5-hydroxytryptophan (5-HTP), serotonin (5HT), DL-5-hydroxyindole-3-acetic acid (5HIAA), and DL-parachlorophenylalanine (pCPA), a serotonin depletor. The pCPA administration, with concomitant reduction of brain serotonin, had no effect on ethanol-induced sleep; TP, 5-HTP and 5HIAA failed also to significantly enhance ethanol sleep in mice. However, serotonin significantly enhanced sleeping time of mice administered an ineffective dose of ethanol. Pretreatment with L-DOPA produced a marked prolongation of ethanol narcosis with a concomitant large increase in whole brain dopamine (DA). Administration of L-DOPA and pCPA, together, produced a smaller augmentation of ethanol effects.

Related Organizations

The University of Texas at Austin
United States

Keywords

Brain Chemistry, Male, Biogenic Amines, Serotonin, Time Factors, Dose-Response Relationship, Drug, Ethanol, Dopamine, Fenclonine, Tryptophan, Hydroxyindoleacetic Acid, Dihydroxyphenylalanine, 5-Hydroxytryptophan, Mice, Norepinephrine, Animals, Sleep

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