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Attenuation of alcohol-induced hypothermia by cyclo (His-Pro) and its analogs

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jun 1995Publisher:Elsevier BVJournal:Neuropeptides, volume 28, pages 351-355 (issn: 0143-4179,

Authors: J Carlton; Haruo Mizuma; Chandan Prasad; Rikhab C. Srimal; S.I Khan; K.B. Mathur; Rakesh Shukla; +2 Authors

doi: 10.1016/0143-4179(95)90100-0

pmid: 7666954

Attenuation of alcohol-induced hypothermia by cyclo (His-Pro) and its analogs

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Abstract

Acute administration of cyclo (His-Pro) to rats cause a dose-dependent decrease in ethanol-induced hypothermia. Bromination of the imidazole moiety of histidine in cyclo (His-Pro) resulted in a significant increase in its potency to attenuate ethanol hypothermia. In contrast, benzylation of the imidazole moiety of histidine or the substitution of one or both of the amino acids in cyclo(His-Pro) led to a total loss of its thermomodulatory activity. In conclusion, it appears from these preliminary data that it may be possible to design analogs of CHP that may be effective antagonists for ethanol hypothermia.

Related Organizations

University Medical Center New Orleans
United States
Louisiana State University
United States
Central Drug Research Institute
India
Central Drug Research Institute
India
University Medical Center New Orleans
United States

Keywords

Bromides, Male, Ethanol, Hypothermia, Peptides, Cyclic, Piperazines, Rats, Rats, Sprague-Dawley, Structure-Activity Relationship, Animals

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