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Effects of nitrendipine, chlordiazepoxide, flumazenil and baclofen on the increased anxiety resulting from alcohol withdrawal

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jan 1992 Italy Publisher:Elsevier BVJournal:Progress in Neuro-Psychopharmacology and Biological Psychiatry, volume 16, pages IN3-93 (issn: 0278-5846,

Authors: File, SE; Zharkovsky, A; HITCHCOTT, PAUL KENNETH;

doi: 10.1016/0278-5846(92)90011-3

pmid: 1557510

handle: 11584/222744

Effects of nitrendipine, chlordiazepoxide, flumazenil and baclofen on the increased anxiety resulting from alcohol withdrawal

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Abstract

1. Male hooded Lister rats were fed a liquid diet containing 10% absolute ethanol for 4-5 weeks. Control rats received the liquid diet in amounts controlled to produce equal weight gain. 2. The rats were tested 7.5 h after withdrawal of ethanol and 30 min after i.p. injection with nitrendipine, chlordiazepoxide or baclofen or 20 min after i.p. injection with flumazenil. 3. Nitrendipine (25-100 mg/kg) was unable to reverse the anxiogenic responses detected on withdrawal from ethanol, but the highest dose did reduce withdrawal tremor. 4. Chlordiazepoxide (10 mg/kg), flumazenil (4 mg/kg) and baclofen (1.25 mg/kg) significantly reversed the anxiogenic response detected on withdrawal from ethanol. 5. These reversals of ethanol withdrawal responses are similar to the reversal of the increased anxiety detected on withdrawal from chronic treatment with benzodiazepines. 6. The mechanisms and clinical implications of these drug-induced reversals are discussed.

Country

Italy

Related Organizations

Guy's Hospital
United Kingdom
Guy's Hospital
United Kingdom
University of London
United Kingdom
University of Cagliari
Italy
Guy's and St Thomas' NHS Foundation Trust
United Kingdom

Keywords

Flumazenil, Male, Baclofen, Diazepam, Anxiety; Benzodiazepines; Calcium; Ethanol; GABAn; Withdrawal., Ethanol, Nitrendipine, Chlordiazepoxide, Anxiety, Rats, Substance Withdrawal Syndrome, Tremor, Animals, Interpersonal Relations

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