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Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Sep 1983Publisher:Elsevier BVJournal:Neuroscience Letters, volume 40, pages 187-192 (issn: 0304-3940,

Copyright policy )Funded by:RCN | Telomere length, epigenet..., NIH | NEURODEGENERATION IN HIV ..., NIH | Leukocyte Telomere Length... +1 projects

Authors: Marco Trabucchi; Laura Lucchi; PierFranco Spano; Helene Anthopoulou; Vito Covelli;

doi: 10.1016/0304-3940(83)90300-2

pmid: 6314211

Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum

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Abstract

Chronic ethanol consumption induces an increase in striatal adenylate cyclase enzymatic activity but is unable to further potentiate the dopamine stimulated production of cyclic-AMP. In striatal membranes obtained from chronic ethanol-treated rats, apomorphine exerts a more potent inhibition of [3H]spiperone binding when compared with controls, demonstrating that ethanol increases the affinity of the dopaminergic receptors associated with adenylate cyclase activity. In addition, GTP is unable to modify the agonist component of dopamine receptor in membrane exposed 'in vivo' to ethanol. Data are discussed in terms of a derangement of receptor-adenylate cyclase coupling system produced by chronic ethanol treatment.

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Keywords

Male, Alcohol Drinking, Apomorphine, Ethanol, Dopamine, Synaptic Membranes, Rats, Inbred Strains, Synaptic Transmission, Corpus Striatum, Rats, Receptors, Dopamine, Spiperone, Cyclic AMP, Animals, Guanosine Triphosphate, Adenylyl Cyclases

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