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Acute ethanol and acetaldehyde administration produce similar effects on L-type calcium channels in rat brain

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jul 1988 Italy Publisher:Elsevier BVJournal:Alcohol, volume 5, pages 337-340 (issn: 0741-8329,

Authors: Bergamaschi S; Rius RA; Trabucchi M.; GOVONI, STEFANO;

doi: 10.1016/0741-8329(88)90076-6

pmid: 2852497

handle: 11571/440876

Acute ethanol and acetaldehyde administration produce similar effects on L-type calcium channels in rat brain

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Abstract

The present study investigates the effect of acute ethanol and acetaldehyde administration on neuronal L-type calcium channels by measuring the binding of 3H-nitrendipine (3H-NTP). Acute ethanol (3 g/kg orally) transiently increases (+40% at 40 min) 3H-NTP binding. Acetaldehyde has a similar effect, but the onset of action is shorter; in fact the binding increase peaks 15 min following administration and is completely reversible within 2 hours. Disulfiram pretreatment does not modify the effect produced by acute ethanol on 3H-NTP binding. The results indicate that acetaldehyde may participate in mediating the action of ethanol on voltage sensitive L-type calcium channels with consequent alterations of neuronal excitability.

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Italy

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Keywords

Brain Chemistry, Cerebral Cortex, Male, Ethanol, Nitrendipine, 610, Brain, Rats, Inbred Strains, Acetaldehyde, Acetates, Receptors, Nicotinic, Rats, Kinetics, Animals, Calcium Channels

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