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Oral self-administration of ethanol and not experimenter-administered ethanol facilitates rewarding electrical brain stimulation

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 May 1990Publisher:Elsevier BVJournal:Alcohol, volume 7, pages 221-225 (issn: 0741-8329,

Authors: M. Moolten; Conan Kornetsky;

doi: 10.1016/0741-8329(90)90008-z

pmid: 2184835

Oral self-administration of ethanol and not experimenter-administered ethanol facilitates rewarding electrical brain stimulation

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Abstract

The effects of ethanol on brain-stimulation reward (BSR) were investigated in rats orally self-administering ethanol. Electrodes were stereotaxically implanted in the medial forebrain bundle (MFB) of male F-344 rats. A rate free threshold procedure was used. Animals demonstrated significant threshold-lowering effects after considerable ethanol self-administration experience. To elucidate the significance of the contingent nature of the route of administration in the threshold-lowering effects of ethanol on BSR, a comparison of animals self-administering ethanol to yoked animals receiving it passively through a gastric cannula was made. Significant threshold-lowering effects were only found in the animals self-administering ethanol and not those receiving it noncontingently. Thus, to the extent that brain-stimulation reward is a model of drug-induced euphoria, these results suggest that the reinforcing effects of ethanol are dependent to a greater degree on an interaction between experimental, environmental and pharmacological factors, than other abused drugs.

Related Organizations

Boston University
United States
Boston College
United States
Boston University School of Medicine / Department of Medicine
United States

Keywords

Alcohol Drinking, Ethanol, Brain, Self Administration, Electric Stimulation, Reward, Animals, Humans

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