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Maternal alcohol ingestion inhibits fetal glucose uptake and growth

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 May 1989Publisher:Elsevier BVJournal:Neurotoxicology and Teratology, volume 11, pages 215-219 (issn: 0892-0362,

Authors: Sant P. Singh; Gordon L. Pullen; Gordon L. Pullen; Ann K. Snyder; Ann K. Snyder;

doi: 10.1016/0892-0362(89)90061-5

pmid: 2755417

Maternal alcohol ingestion inhibits fetal glucose uptake and growth

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Abstract

The distribution of maternally-derived glucose was determined in selected tissues of fetuses from ethanol-fed (EF) rats and from pair-fed (PF) and ad lib-fed (AF) controls. Maternal ethanol ingestion resulted in reduced fetal brain and liver weights and lower liver and lung glycogen levels compared to those of the PF or AF control groups. In addition, experimental fetuses exhibited reduced uptake of maternally-derived [3H] 2-deoxy-D-glucose (2-DG) by placenta and fetal brain. Fetal body, liver, lung, and brain weights correlated with fetal plasma 3H activity and with the fetal:maternal plasma 3H ratio, an indicator of the rate of placental glucose transfer. Brain weight correlated with 2-DG content per gram tissue weight. These observations suggest that reduced nutrient availability due to impaired placental transfer plays a role in the intrauterine growth retardation associated with maternal ethanol ingestion.

Related Organizations

United States Department of the Interior
United States
Rosalind Franklin University of Medicine and Science
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Rosalind Franklin University of Medicine and Science
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United States Department of the Interior
United States

Keywords

Blood Glucose, Ethanol, Placenta, Brain, Rats, Inbred Strains, Organ Size, Rats, Embryonic and Fetal Development, Glucose, Liver, Pregnancy, Animals, Female, Lung, Maternal-Fetal Exchange

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