Abstract Design and fabrication methods translated from microfluidics, microelectromechanical systems, origami, and biologically inspired engineering may offer efficiency improvements for water-based thermoregulation in buildings. This paper introduces foldable radiant cooling devices that are fabricated by lamination with integrated microfluidic water-circuits. These devices produce more surface convection because of their geometry and because they have more surface area than flat panels. As a result, lukewarm water instead of chilled water may be sufficient for cooling a room, leading to potential savings in primary energy use and lifecycle greenhouse gas emissions. Analytical models and physical experiments show a 55–67% improvement in thermal performance when comparing these novel folded surfaces to flat surfaces, mainly due to the improved convection heat transfer.