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Serum β-glucuronidase activity in a population of ex-coalminers

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Nov 1999 Netherlands Publisher:Elsevier BVJournal:Clinical Biochemistry, volume 32, pages 659-664 (issn: 0009-9120,

Authors: Cobben, N.A.M.; Drent, M.; Vries, J. de; Wouters, E.F.M.; Dieijen-Visser, M.P.; Henderson, R.F.;

doi: 10.1016/s0009-9120(99)00070-3

pmid: 10638950

Serum β-glucuronidase activity in a population of ex-coalminers

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Abstract

The aim of this study was to investigate whether BGD activity is of additional value in the assessment of pulmonary inflammation caused by coal dust exposure.Ex-coalminers were included in this study. Forty-eight healthy male subjects, without a relevant medical history, were used as controls.In ex-coalminers serum BGD activity was higher compared to the control group. Moreover, ex-coalminers with a normal chest radiograph and normal serum LDH demonstrated elevated serum BGD compared to the control group. However, no relation was found in the total group of ex-coalminers between serum BGD activity and pulmonary function parameters.Our study adds in vivo human evidence to the already existing animal data that BGD is a potential biomarker useful in monitoring pulmonary inflammation caused by coal dust exposure.

Country

Netherlands

Related Organizations

Maastricht University
Netherlands
Lovelace Respiratory Research Institute
United States
Tilburg University Tilburg University Research Portal
Netherlands
Lovelace Respiratory Research Institute
United States
Tilburg University
Netherlands

Keywords

Lung Diseases, Male, Smoking, Vital Capacity, Dust, Middle Aged, Coal Mining, Occupational Diseases, Coal, Reference Values, Forced Expiratory Volume, Humans, Biomarkers, Aged, Environmental Monitoring, Glucuronidase

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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average