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Comparison of the protective effect of (R)-α-methylhistamine and its prodrugs on gastric mucosal damage induced by ethanol in the rat

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Dec 1996 Italy Publisher:Elsevier BVJournal:General Pharmacology: The Vascular System, volume 27, pages 1,391-1,394 (issn: 0306-3623,

Authors: MORINI, Giuseppina; GRANDI, Daniela; G. Bertaccini;

doi: 10.1016/s0306-3623(96)00068-7

pmid: 9304413

handle: 11381/2636057

Comparison of the protective effect of (R)-α-methylhistamine and its prodrugs on gastric mucosal damage induced by ethanol in the rat

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Abstract

1. The gastroprotective activity of two azomethine prodrugs of (R)-alpha-methylhistamine was examined in lesions induced by absolute ethanol (1 ml/rat intragastrically for 1 h). 2. Pretreatment with (R)-alpha-methylhistamine as well as with the prodrugs (30 and 100 mg/kg intragastrically [IG]) significantly reduced macroscopically visible lesions caused by ethanol, with protection being almost complete at 100 mg/kg. 3. Histologically, in rats pretreated with the three compounds at a dose of 100 mg/kg, the evidence of damage was rare, with the appearance of gastric mucosa being similar in the different groups. 4. Present results are suggestive of a local component in the protective activity of (R)-alpha-methylhistamine.

Country

Italy

Related Organizations

University of Parma
Italy

Keywords

Male, Ethanol, (R)-alpha-methylhistamine, Methylhistamines, 610, azomethine prodrugs, 620, Rats, Histamine Agonists, Necrosis, Gastric Mucosa, gastroprotection, Animals, rat, Prodrugs, ethanol, Rats, Wistar, Gastrointestinal Hemorrhage

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