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Protective effect of Nigella sativa oil against binge ethanol-induced oxidative stress and liver injury in rats

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jul 2014Publisher:Elsevier BVJournal:Chinese Journal of Natural Medicines, volume 12, pages 495-499 (issn: 1875-5364,

Authors: Seval Develi; Betül Evran; Necla Koçak-Toker; Gül Özdemirler Erata; Esra Betül Kalaz;

doi: 10.1016/s1875-5364(14)60077-7

pmid: 25053547

Protective effect of Nigella sativa oil against binge ethanol-induced oxidative stress and liver injury in rats

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Abstract

Nigella sativa L. (Ranunculaceae) is considered as a therapeutic plant-based medicine for liver damage. In this study, the aim was to study the effect of Nigella sativa oil (NSO) pretreatment on ethanol-induced hepatotoxicity in rats.Rats were given Nigella sativa oil at doses of 2.5 and 5.0 mL·kg(-1), orally for 3 weeks, followed by oral ethanol (EtOH) administration (5 g·kg(-1)) every 12 h three times (binge model).Binge ethanol application caused significant increases in plasma transaminase activities and hepatic triglyceride and malondialdehyde (MDA) levels. It decreased hepatic glutathione (GSH) levels, but did not change vitamins E and vitamin C levels and antioxidant enzyme activities. NSO (5.0 mL·kg(-1)) pretreatment significantly decreased plasma transaminase activities, hepatic MDA, and triglyceride levels together with amelioration in hepatic histopathological findings.NSO pretreatment may be effective in protecting oxidative stress-induced hepatotoxicity after ethanol administration.

Related Organizations

Istanbul University
Turkey

Keywords

Ethanol, Superoxide Dismutase, Protective Agents, Rats, Rats, Sprague-Dawley, Disease Models, Animal, Oxidative Stress, Liver, Malondialdehyde, Animals, Humans, Plant Oils, Female, Nigella sativa, Liver Diseases, Alcoholic, Transaminases

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