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Solubility of Budesonide, Hydrocortisone, and Prednisolone in Ethanol + Water Mixtures at 298.2 K

doi: 10.1021/je900376r
handle: 10454/4853
Solubility of Budesonide, Hydrocortisone, and Prednisolone in Ethanol + Water Mixtures at 298.2 K
Experimental solubilities of budesonide, hydrocortisone, and prednisolone in ethanol + water mixtures at 298.2 K are reported. The solubility of drugs was increased with the addition of ethanol and reached the maximum values of the volume fractions of 90 %, 80 %, and 80 % of ethanol. The Jouyban−Acree model was used to fit the experimental data, and the solubilities were reproduced using previously trained versions of the Jouyban−Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 5.1 %, 6.4 %, 37.7 %, and 35.9 %, respectively, for the fitted model, the trained version for ethanol + water mixtures, and generally trained versions for various organic solvents + water mixtures. Solubilities were also predicted by a previously established log−linear model of Yalkowsky with the OMRD of 53.8 %.
- University of North Texas United States
- Assiut University Egypt
- Tabriz University of Medical Sciences Iran (Islamic Republic of)
- Assiut University Egypt
- University of Bradford United Kingdom
budesonide, Loglinear model, Hydrocortisone, Prednisolone, 610, Crystal engineering, Experimental data, Solubility data, F100 - Chemistry, Capillary flow, Maximum values, F170 - Physical chemistry, hydrocortisone, Budesonide, Ethanol, 660, prednisolone, Water mixture, Ethanol and water mixtures, Organic solvents, F170 Physical Chemistry, Solubility, Mixtures, Relative deviations, F100 Chemistry, Jouyban-Acree model, ethanol, Regression analysis, Ternary systems
budesonide, Loglinear model, Hydrocortisone, Prednisolone, 610, Crystal engineering, Experimental data, Solubility data, F100 - Chemistry, Capillary flow, Maximum values, F170 - Physical chemistry, hydrocortisone, Budesonide, Ethanol, 660, prednisolone, Water mixture, Ethanol and water mixtures, Organic solvents, F170 Physical Chemistry, Solubility, Mixtures, Relative deviations, F100 Chemistry, Jouyban-Acree model, ethanol, Regression analysis, Ternary systems
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