The study area of Rmel-O. Ogbane aquifer, located in the north of Morocco, currently faces major water challenges related to the sustainable management of water resources. Climate change and Sea-Level-Rise can increase the risks and costs of water resources management and impact water resources' quantity and quality. Hence, for planning and management, an integrated approach is developed for linking climate models and groundwater models to investigate future impacts of climate change on groundwater resources. Climate projections show an increase in temperature of about 0.45 °C and a reduction in precipitation of 16.7% for 2016-2050. Simulations of seawater intrusion corresponding to various combinations of groundwater extraction predicted climate change and sea-level-rise show that the area will be contaminated on the NW sector of the coastal part. The toe would reach about 5.2 km inland and intrude on high salinity (15–25g/l). Beyond these zones, the contamination of the aquifer will be limited. Moreover, these results were confirmed by the application of the GALDIT method. They reveal that the fringe littoral areas of the aquifer are the most affected by seawater intrusion, with a high risk in the north-western part of the study area.