Evolution of TNF-induced apoptosis reveals 550 My of functional conservation
Copyright policy )Evolution of TNF-induced apoptosis reveals 550 My of functional conservation
Significance The TNF receptor-ligand superfamily is a central mediator of apoptosis or programmed cell death. Here we show that TNF-induced apoptosis has been functionally maintained for more than half a billion years of evolution. In response to human TNFα, coral cells underwent the classical stages of apoptosis including cellular blebbing, caspase activation, and eventual cell death. Next, the reciprocal experiment showed that coral TNF kills human cells through direct interaction with the death receptor pathway. In addition, corals were found to possess more putative TNF receptors than any organism previously described, including humans. This work provides important insight into the general evolution of apoptosis and demonstrates remarkable conservation of the TNF apoptotic response.
- University of California System United States
- San Diego State University United States
- Scripps Institution of Oceanography United States
- Cedars-Sinai Smidt Heart Institute United States
- University of California, San Diego United States
Electrophoresis, invertebrate immunity, 1.1 Normal biological development and functioning, Cells, Fas-Associated Death Domain Protein, Adaptation, Biological, 610, Apoptosis, Fluorescence, Receptors, Tumor Necrosis Factor, evolution immunity, Gene Knockout Techniques, Jurkat Cells, Species Specificity, Underpinning research, Death Domain, Receptors, Animals, Humans, Cnidarians, Electrophoresis, Gel, Two-Dimensional, Adaptation, Life Below Water, Cells, Cultured, Gel, Microscopy, Cultured, Ecology, Tumor Necrosis Factor-alpha, Computational Biology, Receptors, Death Domain, Biological Sciences, Biological, Anthozoa, Flow Cytometry, Biological Evolution, Immunohistochemistry, cytokines, climate change, Microscopy, Fluorescence, Two-Dimensional, Biochemistry and Cell Biology, Tumor Necrosis Factor
Electrophoresis, invertebrate immunity, 1.1 Normal biological development and functioning, Cells, Fas-Associated Death Domain Protein, Adaptation, Biological, 610, Apoptosis, Fluorescence, Receptors, Tumor Necrosis Factor, evolution immunity, Gene Knockout Techniques, Jurkat Cells, Species Specificity, Underpinning research, Death Domain, Receptors, Animals, Humans, Cnidarians, Electrophoresis, Gel, Two-Dimensional, Adaptation, Life Below Water, Cells, Cultured, Gel, Microscopy, Cultured, Ecology, Tumor Necrosis Factor-alpha, Computational Biology, Receptors, Death Domain, Biological Sciences, Biological, Anthozoa, Flow Cytometry, Biological Evolution, Immunohistochemistry, cytokines, climate change, Microscopy, Fluorescence, Two-Dimensional, Biochemistry and Cell Biology, Tumor Necrosis Factor
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