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Evaluation of the anti-Leishmaniaactivity of ethanol extract and fractions of the leaves fromPityrogramma calomelanos(L.) link

Authors: Henrique Douglas Melo Coutinho; Maria Flaviana Bezerra Morais-Braga; José Galberto Martins da Costa; Irwin Rose Alencar de Menezes; Teógenes M. Souza; Antônio A.F. Saraiva; Celeste Vega; +2 Authors

Evaluation of the anti-Leishmaniaactivity of ethanol extract and fractions of the leaves fromPityrogramma calomelanos(L.) link

Abstract

Leishmaniasis is caused by parasites of the genus Leishmania. Recent reports about leishmaniasis show a few number of drugs available, indicating the necessity of new drugs. In this study, the ethanol extract and fractions of Pityrogramma calomelanos (L.) link. (Pteridaceae) were assayed to verify the cytotoxicity and in vitro leishmanicidal activity against promastigote forms of Leishmania brasiliensis. The cytotoxic assay was performed using fibroblasts NCTC929. The studies indicated a leishmanicidal effect of the ethanol extract and the ethyl-acetate fraction. However, a high cytotoxic effect was observed. The hexane and methanol fractions did not show leishmanicidal activity, nor cytotoxic effect. The phytochemical screening detected the presence of alkaloids, a class of secondary metabolites with a known leishmanicidal activity. This is the first study reporting an anti-Leishmania and cytotoxic effect of P. calomelanos, being an interesting approach in the search for drugs against this disease.

Keywords

Leishmania, Plant Leaves, Ethanol, Plant Extracts, Drug Evaluation, Preclinical, Ferns, Animals

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
5
Average
Average
Average
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