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Additive effect of Lygodium venustum SW. in association with gentamicin

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type , Journal 18 Aug 2015Publisher:Informa UK LimitedJournal:Natural Product Research, volume 30, pages 1,851-1,853 (issn: 1478-6419, eissn: 1478-6427,

Authors: Saulo R. Tintino; Maria Flaviana Bezerra Morais-Braga; Karla K.A. Santos; Gláucia M.M. Guedes; Teógenes M. Souza; Celestina E. Sobral-Souza; Jacqueline Cosmo Andrade; +3 Authors

doi: 10.1080/14786419.2015.1074227 , 10.6084/m9.figshare.1568123.v1 , 10.6084/m9.figshare.1568123

pmid: 26284428

Additive effect of Lygodium venustum SW. in association with gentamicin

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Abstract

The aim of this work was to evaluate the interactions between gentamicin and the ethanol extract of the fern Lygodium venustum SW (EELV). The ethanol extract of L. venustum was obtained, the phytocompounds were identified and the EELV was assayed by the checkerboard method with gentamicin against two bacterial strains multiresistant to antibiotics. The antibiotic activity of gentamicin, when associated with the extract, was enhanced in an additive manner against both strains. The results indicated that L. venustum can be a source of secondary metabolites to be used in association with antibiotics as aminoglycosides in the antibiotic chemotherapy against resistant bacteria.

Related Organizations

Universidade Regional do Cariri
Brazil
Universidade Regional do Cariri
Brazil

Keywords

Staphylococcus aureus, Ethanol, Plant Extracts, Drug Evaluation, Preclinical, Drug Synergism, Microbial Sensitivity Tests, Anti-Bacterial Agents, Drug Resistance, Multiple, Bacterial, Escherichia coli, Ferns, Gentamicins

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