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Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Aug 2002Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:Neuroreport, volume 13, pages 1,509-1,513 (issn: 0959-4965,

Authors: Geon Ho Bahn; Yunhee Kim Kwon; Min Chul Shin; Sae Bin Jung; Ee Hwa Kim; Chang-Ju Kim; Taeck Hyun Lee; +1 Authors

doi: 10.1097/00001756-200208270-00004

pmid: 12218695

Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus

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Abstract

It is generally accepted that alcohol and nicotine affect learning ability and memory functions, especially in adolescents. In the present study, the effects of alcohol and nicotine on cell proliferation and apoptosis in the dentate gyrus of young rats were investigated. The results show that cell proliferation is suppressed by alcohol and nicotine. Furthermore, alcohol and nicotine increase the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive cells. Based on the results presented in this study, it can be suggested that alcohol- and nicotine-related impairment in learning and memory functions may be due to alcohol- and nicotine-induced suppression of new cell formation and acceleration of apoptosis, especially during adolescence.

Related Organizations

Kyung Hee University
Korea (Republic of)
Kyung Hee University
Korea (Republic of)

Keywords

Male, Nicotine, Ethanol, Antimetabolites, Central Nervous System Depressants, Apoptosis, Immunohistochemistry, Rats, Rats, Sprague-Dawley, Bromodeoxyuridine, Dentate Gyrus, In Situ Nick-End Labeling, Animals, Nicotinic Agonists, Cell Division

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	81
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%