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Ethanol Induces Marked Changes in Lymphocyte Populations and Natural Killer Cell Activity in Mice

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jun 1992Publisher:WileyJournal:Alcoholism: Clinical and Experimental Research, volume 16, pages 474-479 (issn: 0145-6008, eissn: 1530-0277,

Authors: John Wunderlich; Gary G. Meadows; Dinah S. Singer; Michele Wallendal; Atsushi Kosugi;

doi: 10.1111/j.1530-0277.1992.tb01403.x

pmid: 1626648

Ethanol Induces Marked Changes in Lymphocyte Populations and Natural Killer Cell Activity in Mice

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Abstract

Treatment of mice in vivo with 5% w/v ethanol given in a liquid diet causes marked changes in spleen, peripheral blood, and thymus lymphocytes. In both the thymus and spleen, there is an acute cellular depletion resulting in a significant decrease in gross tissue size and cell number. In spleen and peripheral blood, the percentage of T lymphocytes is increased relative to B lymphocytes, but the ratio of CD4+/CD8+ T cell sub‐populations remains unchanged. Splenic natural killer (NK) cell activity is increased in ethanol‐consuming mice, although the percentage of NK1.1+ cells is relatively unchanged.

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Keywords

Cytotoxicity, Immunologic, Alcohol Drinking, Ethanol, Mice, Inbred Strains, Thymus Gland, Lymphocyte Subsets, Killer Cells, Natural, Major Histocompatibility Complex, Alcoholism, Leukocyte Count, Mice, Liver, Animals, Spleen

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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%