<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Glutathione prevents ethanol induced gastric mucosal damage and depletion of sulfhydryl compounds in humans.

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Feb 1993 Italy Publisher:BMJJournal:Gut, volume 34, pages 161-165 (issn: 0017-5749,

Authors: LOGUERCIO, Carmelina; D. TARANTO; F. BENEDUCE; C. DEL VECCHIO BLANCO; A. DE VINCENTIIS; G. NARDI; ROMANO, Marco;

doi: 10.1136/gut.34.2.161

pmid: 8432465

pmc: PMC1373962

handle: 11591/235865

Glutathione prevents ethanol induced gastric mucosal damage and depletion of sulfhydryl compounds in humans.

- Summary
- Subjects
- Metrics

Abstract

Whether parenteral administration of reduced glutathione prevented ethanol induced damage to and depletion of sulfhydryl compounds in the human gastric mucosa was investigated. Ten healthy volunteers underwent endoscopy on three separate occasions. Gastric mucosal damage was induced by spraying 80% ethanol on to the gastric mucosa through the biopsy channel of the endoscope. The gastric mucosal score, total sulfhydryls, glutathione, and cysteine were evaluated in basal conditions and after ethanol administration with and without pretreatment with parenteral glutathione. Glutathione significantly decreased the extent of ethanol induced macroscopic injury to the mucosa of the gastric body and antrum. Glutathione's protective effect is associated with appreciable inhibition of ethanol induced depletion of gastric sulfhydryl compounds. This is the first report of protection against ethanol induced gastric mucosal damage by a sulfhydryl containing agent in humans.

Country

Italy

Related Organizations

Keywords

Adult, Ethanol, Stomach, Middle Aged, Glutathione, Gastric Mucosa, Pyloric Antrum, Humans, Female, Cysteine, Sulfhydryl Compounds

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	90
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%