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How toxic are propoxyphene and ethanol in combination?

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jun 1984Publisher:Canadian Science PublishingJournal:Canadian Journal of Physiology and Pharmacology, volume 62, pages 700-703 (issn: 0008-4212, eissn: 1205-7541,

Authors: R. J. Reiffenstein; Manuel Mah;

doi: 10.1139/y84-115

pmid: 6744114

How toxic are propoxyphene and ethanol in combination?

- Summary
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Abstract

Ethanol has been claimed to potentiate greatly the lethality of propoxyphene, although published clinical data suggest only an additive effect. Mice were treated intraperitoneally with various doses of propoxyphene hydrochloride and ethanol. Isobolograms of the data show the combination to be less-than-additive for lethality and loss of motor coordination and, at worst, simply additive for sedation.

Keywords

Dextropropoxyphene, Mice, Inbred ICR, Behavior, Animal, Ethanol, Lethal Dose 50, Mice, Animals, Drug Interactions, Female

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	6
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average