In the present paper, two experiments are performed to test the efficacy of the intravenous administration of hypertonic glucose (25 or 50%) in alcoholic intoxication. In a first experiment, 10 healthy, nonstarved volunteers, received 15 min after the ingestion of 1.0 g/kg alcohol, 40 ml of 25% glucose i.v., the same volume of 0.9% NaCl or no injection. According to evaluations performed at several time intervals up to 2 h after alcohol ingestion, no difference among the 3 conditions was observed either in the intensity of alcohol intoxication or on blood alcohol levels. In a second experiment, blood glucose and alcohol levels were evaluated in 80 alcoholized patients in an emergency room. The mean glycemic value was 94 mg/100 ml. No difference was found by comparing this value with that presented by nonalcoholized patients. The 80 patients were distributed in two groups of 40 each: one of them was intravenously administered 40 ml of glucose 50% while the other was injected with saline. About 20-30 min later the patients of both groups were clinically evaluated by the physician on duty, being considered equally improved regardless of the injection. The self-evaluation by the patients provided similar results.