Negative environmental changes generally addressed as ‘syndromes’ areevaluated in the context of Soil Degradation (SD) and interpreted by usinga ‘Land-Use/Land Cover Changes’ (LULCCs) framework in order to dis-entangle ‘past trajectories’, ‘present patterns’, and ‘future changes’. Thisapproach allows to discuss the potential impact on SD processes and itrepresents an informed basis for identifying measurable outcomes of SD.This study focuses on the case of Emilia Romagna, a region located inthe North of Italy with high-value added agricultural productions. A multi-temporal analysis of land-use changes between 1954 and 2008 has been proposed, discussing the evolution of associated SD syndromes in EmiliaRomagna. The contributing information have been used as a baseline forSustainable Land Management (SLM) strategies. This framework of analysisprovides useful tools to investigate and to monitor the effects of SD in theMediterranean basin where several regions underwent common developmentpatterns yelding global pathological symptoms of environmental degradation.